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    F42G2.5 Major sperm protein [ Caenorhabditis elegans ]

    Gene ID: 185673, updated on 9-Dec-2024

    Summary

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    Official Symbol
    F42G2.5
    Official Full Name
    Major sperm protein
    Primary source
    WormBase:WBGene00018354
    Locus tag
    CELE_F42G2.5
    See related
    AllianceGenome:WB:WBGene00018354
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein-membrane adaptor activity. Predicted to be involved in endoplasmic reticulum membrane organization and endoplasmic reticulum-plasma membrane tethering. Predicted to be located in cytoskeleton. Predicted to be active in endoplasmic reticulum membrane and plasma membrane. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 8; autosomal dominant adult-onset proximal spinal muscular atrophy; and spinal muscular atrophy. Orthologous to human VAPA (VAMP associated protein A) and VAPB (VAMP associated protein B and C). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See F42G2.5 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    7
    Sequence:
    Chromosome: II; NC_003280.10 (2415997..2417989, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene FTH domain-containing protein Neighboring gene F-box domain-containing protein Neighboring gene Phytanoyl-CoA dioxygenase;phytanoyl-CoA dioxygenase Neighboring gene F-box C protein Neighboring gene ncRNA Neighboring gene DUF38 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of cross-linked peptides from complex samples. Yang B, et al. Nat Methods, 2012 Sep. PMID 22772728
    2. Interactions within the ubiquitin pathway of Caenorhabditis elegans. Gudgen M, et al. Biochem Biophys Res Commun, 2004 Dec 10. PMID 15530417
    3. Shifted Transversal Design smart-pooling for high coverage interactome mapping. Xin X, et al. Genome Res, 2009 Jul. PMID 19447967, Free PMC Article
    4. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-membrane adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum membrane organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum-plasma membrane tethering IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Major sperm protein
    NP_494271.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      2415997..2417989 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_061870.2 → NP_494271.1  Major sperm protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_494271.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O17099
      Conserved Domains (3) summary
      smart00184
      Location:134 → 178
      RING; Ring finger
      pfam00635
      Location:7 → 110
      Motile_Sperm; MSP (Major sperm protein) domain
      pfam15905
      Location:174 → 329
      HMMR_N; Hyaluronan mediated motility receptor N-terminal
    Nucleotide Protein
    Heading Accession and Version

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