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    rund-1 RUN domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180416, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rund-1
    Official Full Name
    RUN domain-containing protein
    Primary source
    WormBase:WBGene00020572
    Locus tag
    CELE_T19D7.4
    See related
    AllianceGenome:WB:WBGene00020572
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables small GTPase binding activity. Involved in several processes, including dense core granule maturation; positive regulation of behavior; and positive regulation of dense core granule transport. Located in several cellular components, including Golgi trans cisterna; neuronal cell body; and perinuclear region of cytoplasm. Is expressed in several structures, including gonad; intestine; nervous system; pharynx; and rectal gland cell. Orthologous to human RUNDC1 (RUN domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rund-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    11
    Sequence:
    Chromosome: X; NC_003284.9 (658477..661777, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Galectin Neighboring gene IF rod domain-containing protein;Intermediate Filament, C;Intermediate filament protein ifc-2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene LiPocalin-Related protein Neighboring gene ncRNA Neighboring gene Transmembrane protein Neighboring gene ncRNA Neighboring gene LRRcap domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fast genetic mapping using insertion-deletion polymorphisms in Caenorhabditis elegans. Hwang HY, et al. Sci Rep, 2021 May 26. PMID 34040027, Free PMC Article
    2. Two Rab2 interactors regulate dense-core vesicle maturation. Ailion M, et al. Neuron, 2014 Apr 2. PMID 24698274, Free PMC Article
    3. The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo Sorting to Dense-Core Vesicles. Topalidou I, et al. PLoS Genet, 2016 May. PMID 27191843, Free PMC Article
    4. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dense core granule maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of dense core granule transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of dense core granule transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of egg-laying behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of locomotion involved in locomotory behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of dauer larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of defecation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of locomotion involved in locomotory behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of locomotion involved in locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi trans cisterna IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RUN domain-containing protein
    NP_508136.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      658477..661777 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075735.8 → NP_508136.2  RUN domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508136.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22585, X2C018
      Conserved Domains (2) summary
      COG1196
      Location:45 → 256
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd17683
      Location:225 → 534
      RUN_RUNDC1; RUN domain found in RUN domain-containing protein 1 (RUNDC1) and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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