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    lhpp-1 Phospholysine phosphohistidine inorganic pyrophosphate phosphatase [ Caenorhabditis elegans ]

    Gene ID: 179661, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lhpp-1
    Official Full Name
    Phospholysine phosphohistidine inorganic pyrophosphate phosphatase
    Primary source
    WormBase:WBGene00007548
    Locus tag
    CELE_C13C4.4
    See related
    AllianceGenome:WB:WBGene00007548
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable inorganic diphosphate phosphatase activity and phosphatase activity. Predicted to be involved in dephosphorylation. Predicted to be located in nucleus. Predicted to be active in cytosol. Is expressed in nervous system and reproductive system. Orthologous to human LHPP (phospholysine phosphohistidine inorganic pyrophosphate phosphatase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lhpp-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (12109046..12111805, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Nuclear hormone receptor family member nhr-154 Neighboring gene Nuclear hormone receptor family member nhr-153 Neighboring gene Nuclear hormone receptor family member nhr-136;Nuclear receptor domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dose-dependent functions of SWI/SNF BAF in permitting and inhibiting cell proliferation in vivo. van der Vaart A, et al. Sci Adv, 2020 May. PMID 32494730, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables inorganic diphosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Phospholysine phosphohistidine inorganic pyrophosphate phosphatase
    NP_506040.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      12109046..12111805 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073639.5 → NP_506040.1  Phospholysine phosphohistidine inorganic pyrophosphate phosphatase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506040.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O01926
      Conserved Domains (3) summary
      TIGR01458
      Location:7 → 262
      HAD-SF-IIA-hyp3; HAD-superfamily subfamily IIA hydrolase, TIGR01458
      pfam13242
      Location:184 → 255
      Hydrolase_like; HAD-hyrolase-like
      pfam13344
      Location:10 → 91
      Hydrolase_6; Haloacid dehalogenase-like hydrolase
    Nucleotide Protein
    Heading Accession and Version

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