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    hlb-1 Liprin-beta homolog [ Caenorhabditis elegans ]

    Gene ID: 181499, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hlb-1
    Official Full Name
    Liprin-beta homolog
    Primary source
    WormBase:WBGene00011904
    Locus tag
    CELE_T21H8.1
    See related
    AllianceGenome:WB:WBGene00011904
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in neuromuscular junction development; positive regulation of locomotion; and regulation of nematode pharyngeal pumping. Predicted to be active in presynaptic active zone. Orthologous to human PPFIBP1 (PPFIA binding protein 1) and PPFIBP2 (PPFIA binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hlb-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    20
    Sequence:
    Chromosome: X; NC_003284.9 (13865033..13882739, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bi-allelic loss-of-function variants in PPFIBP1 cause a neurodevelopmental disorder with microcephaly, epilepsy, and periventricular calcifications. Rosenhahn E, et al. Am J Hum Genet, 2022 Aug 4. PMID 35830857, Free PMC Article
    2. HLB-1 functions as a new regulator for the organization and function of neuromuscular junctions in nematode Caenorhabditis elegans. Wang DY, et al. Neurosci Bull, 2009 Apr. PMID 19290026, Free PMC Article
    3. Ferritin-mediated iron detoxification promotes hypothermia survival in Caenorhabditis elegans and murine neurons. Pekec T, et al. Nat Commun, 2022 Aug 19. PMID 35986016, Free PMC Article
    4. Regulation of aging by unc-13 and sbt-1 in Caenorhabditis elegans is temperature-dependent. He KW, et al. Neurosci Bull, 2009 Dec. PMID 19927169, Free PMC Article
    5. Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins. Serra-Pagès C, et al. J Biol Chem, 1998 Jun 19. PMID 9624153

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in neuromuscular junction development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuromuscular junction development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of nematode pharyngeal pumping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in presynaptic active zone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Liprin-beta homolog
    NP_001123185.1
    • Partially confirmed by transcript evidence
    NP_001309703.1
    • Partially confirmed by transcript evidence
    NP_001309704.1
    • Partially confirmed by transcript evidence
    NP_001309705.1
    • Confirmed by transcript evidence
    NP_001309706.1
    • Partially confirmed by transcript evidence
    NP_001309707.1
    • Confirmed by transcript evidence
    NP_001309708.1
    • Partially confirmed by transcript evidence
    NP_001309709.1
    • Confirmed by transcript evidence
    NP_001309710.1
    • Partially confirmed by transcript evidence
    NP_001309713.1
    • Confirmed by transcript evidence
    NP_001309714.1
    • Partially confirmed by transcript evidence
    NP_001309716.1
    • Confirmed by transcript evidence
    NP_001309717.1
    • Confirmed by transcript evidence
    NP_001309718.1
    • Partially confirmed by transcript evidence
    NP_001364846.1
    • Partially confirmed by transcript evidence
    NP_001379172.1
    • Confirmed by transcript evidence
    NP_001380196.1
    • Confirmed by transcript evidence
    NP_001380197.1
    • Confirmed by transcript evidence
    NP_510311.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      13865033..13882739 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001322656.4 → NP_001309704.1  Liprin-beta homolog [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MBV4
      Conserved Domains (3) summary
      cd09563
      Location:606 → 669
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:680 → 742
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cl15755
      Location:768 → 839
      SAM_superfamily; SAM (Sterile alpha motif )

    2. NM_001322647.4 → NP_001309707.1  Liprin-beta homolog [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MD98
      Conserved Domains (4) summary
      cd09563
      Location:653 → 716
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:727 → 789
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:815 → 886
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      COG1196
      Location:216 → 427
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    3. NM_001322660.3 → NP_001309706.1  Liprin-beta homolog [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MD42
      Conserved Domains (3) summary
      cd09563
      Location:374 → 437
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:448 → 510
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cl15755
      Location:536 → 607
      SAM_superfamily; SAM (Sterile alpha motif )

    4. NM_001322649.4 → NP_001309709.1  Liprin-beta homolog [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MBE2
      Conserved Domains (4) summary
      cd09563
      Location:627 → 690
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:701 → 763
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:789 → 860
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      COG1196
      Location:190 → 401
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    5. NM_001322650.3 → NP_001309710.1  Liprin-beta homolog [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MBC5
      Conserved Domains (4) summary
      cd09563
      Location:669 → 732
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:743 → 805
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      COG1196
      Location:190 → 401
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl15755
      Location:831 → 902
      SAM_superfamily; SAM (Sterile alpha motif )

    6. NM_077910.5 → NP_510311.2  Liprin-beta homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510311.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94071
      Conserved Domains (4) summary
      cd09563
      Location:611 → 674
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:685 → 747
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      COG1196
      Location:174 → 385
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl15755
      Location:773 → 844
      SAM_superfamily; SAM (Sterile alpha motif )

    7. NM_001129713.4 → NP_001123185.1  Liprin-beta homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001123185.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A7LPI2
      Conserved Domains (4) summary
      cd09563
      Location:653 → 716
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:727 → 789
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      COG1196
      Location:174 → 385
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl15755
      Location:815 → 886
      SAM_superfamily; SAM (Sterile alpha motif )

    8. NM_001322648.4 → NP_001309708.1  Liprin-beta homolog [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A131MBC5, A0A131MBE2, A0A131MBV4, A0A131MBW2, A0A131MBW4, A0A131MBY3, A0A131MBZ3, A0A131MC19, A0A131MC32, A0A131MCT0, A0A131MD42, A0A131MD54, A0A131MD98, A0A131MDA8, A0A131MDI4, A0A131MDJ4, A7LPI2, Q94071, Q94075
      Conserved Domains (4) summary
      cd09563
      Location:695 → 758
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:769 → 831
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:857 → 928
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      COG1196
      Location:216 → 427
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    9. NM_001392878.1 → NP_001380196.1  Liprin-beta homolog [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (4) summary
      cd09563
      Location:561 → 624
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:635 → 697
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      COG1196
      Location:124 → 335
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl15755
      Location:723 → 794
      SAM_superfamily; SAM (Sterile alpha motif )

    10. NM_001377622.2 → NP_001364846.1  Liprin-beta homolog [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (4) summary
      cd09563
      Location:603 → 666
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:677 → 739
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      COG1196
      Location:124 → 335
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl15755
      Location:765 → 836
      SAM_superfamily; SAM (Sterile alpha motif )

    11. NM_001322653.5 → NP_001309713.1  Liprin-beta homolog [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MDJ4
      Conserved Domains (4) summary
      cd09563
      Location:474 → 537
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:548 → 610
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      COG1196
      Location:37 → 248
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl15755
      Location:636 → 707
      SAM_superfamily; SAM (Sterile alpha motif )

    12. NM_001322654.3 → NP_001309714.1  Liprin-beta homolog [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MBW2
      Conserved Domains (4) summary
      cd09563
      Location:516 → 579
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:590 → 652
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      COG1196
      Location:37 → 248
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl15755
      Location:678 → 749
      SAM_superfamily; SAM (Sterile alpha motif )

    13. NM_001322655.3 → NP_001309703.1  Liprin-beta homolog [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MDI4
      Conserved Domains (3) summary
      cd09563
      Location:564 → 627
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:638 → 700
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cl15755
      Location:726 → 797
      SAM_superfamily; SAM (Sterile alpha motif )

    14. NM_001322657.3 → NP_001309717.1  Liprin-beta homolog [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MDA8
      Conserved Domains (4) summary
      cd09563
      Location:462 → 525
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:536 → 598
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      COG1196
      Location:25 → 236
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl15755
      Location:624 → 695
      SAM_superfamily; SAM (Sterile alpha motif )

    15. NM_001322658.3 → NP_001309718.1  Liprin-beta homolog [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MBZ3
      Conserved Domains (4) summary
      cd09563
      Location:504 → 567
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:578 → 640
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      COG1196
      Location:25 → 236
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl15755
      Location:666 → 737
      SAM_superfamily; SAM (Sterile alpha motif )

    16. NM_001322659.3 → NP_001309705.1  Liprin-beta homolog [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MC19
      Conserved Domains (3) summary
      cd09563
      Location:332 → 395
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:406 → 468
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cl15755
      Location:494 → 565
      SAM_superfamily; SAM (Sterile alpha motif )

    17. NM_001392879.1 → NP_001380197.1  Liprin-beta homolog [Caenorhabditis elegans]

      Status: REVIEWED

    18. NM_001392880.1 → NP_001379172.1  Liprin-beta homolog [Caenorhabditis elegans]

      Status: REVIEWED

    19. NM_001322662.1 → NP_001309716.1  Liprin-beta homolog [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MD54
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94071.5

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