U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    csp-2 Putative inactive caspase subunit p14 [ Caenorhabditis elegans ]

    Gene ID: 177391, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    csp-2
    Official Full Name
    Putative inactive caspase subunit p14
    Primary source
    WormBase:WBGene00000820
    Locus tag
    CELE_Y73B6BL.7
    See related
    AllianceGenome:WB:WBGene00000820
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables caspase binding activity; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; and zymogen binding activity. Involved in positive regulation of brood size; positive regulation of fertilization; and regulation of apoptotic process. Part of protease inhibitor complex. Is expressed in germ line. Human ortholog(s) of this gene implicated in ovarian carcinoma. Orthologous to human CASP6 (caspase 6). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See csp-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    16
    Sequence:
    Chromosome: IV; NC_003282.8 (6307739..6315719)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Thioredoxin domain-containing protein Neighboring gene tRNA pseudouridine synthase

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Caspase protocols in Caenorhabditis elegans. Lee ES, et al. Methods Mol Biol, 2014. PMID 24567097
    2. Identification of multiple Caenorhabditis elegans caspases and their potential roles in proteolytic cascades. Shaham S. J Biol Chem, 1998 Dec 25. PMID 9857046
    3. Caenorhabditis elegans caspase homolog CSP-2 inhibits CED-3 autoactivation and apoptosis in germ cells. Geng X, et al. Cell Death Differ, 2009 Oct. PMID 19575016, Free PMC Article
    4. Caspases: an ancient cellular sword of Damocles. Boyce M, et al. Cell Death Differ, 2004 Jan. PMID 14647235
    5. Intertwined Functions of Separase and Caspase in Cell Division and Programmed Cell Death. Jeong PY, et al. Sci Rep, 2020 Apr 9. PMID 32273538, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables caspase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables caspase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zymogen binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of cysteine-type endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process involved in development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of brood size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of fertilization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protease inhibitor complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Putative inactive caspase subunit p14
    NP_001368631.1
    • Confirmed by transcript evidence
    NP_001368632.1
    • Confirmed by transcript evidence
    NP_001370851.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      6307739..6315719
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001383103.2 → NP_001370851.1  Putative inactive caspase subunit p14 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (3) summary
      PHA03418
      Location:475 → 563
      PHA03418; hypothetical E4 protein; Provisional
      cd00032
      Location:581 → 824
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      NF033930
      Location:239 → 533
      pneumo_PspA; pneumococcal surface protein A

    2. NM_001380264.1 → NP_001368632.1  Putative inactive caspase subunit p14 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (3) summary
      PHA03418
      Location:376 → 464
      PHA03418; hypothetical E4 protein; Provisional
      cd00032
      Location:482 → 725
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      NF033930
      Location:140 → 434
      pneumo_PspA; pneumococcal surface protein A

    3. NM_001380265.1 → NP_001368631.1  Putative inactive caspase subunit p14 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1N7SZF9, G5ECY5, Q9TZP5
      Conserved Domains (1) summary
      cd00032
      Location:18 → 261
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9TZP5.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools