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    M18.6 CULT domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 187461, updated on 9-Dec-2024

    Summary

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    Official Symbol
    M18.6
    Official Full Name
    CULT domain-containing protein
    Primary source
    WormBase:WBGene00010891
    Locus tag
    CELE_M18.6
    See related
    AllianceGenome:WB:WBGene00010891
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in protein ubiquitination. Predicted to be part of Cul4A-RING E3 ubiquitin ligase complex. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 2. Orthologous to human CRBN (cereblon). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See M18.6 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (12121310..12122882)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene DNA damage-binding protein 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Chromatin target of PRMT1 protein C-terminal domain-containing protein Neighboring gene Palmitoyltransferase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul4A-RING E3 ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    CULT domain-containing protein
    NP_001293924.1
    • Confirmed by transcript evidence
    NP_502300.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      12121310..12122882
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001306995.3 → NP_001293924.1  CULT domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293924.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061ACL6
      Conserved Domains (3) summary
      smart00464
      Location:35 → 102
      LON; Found in ATP-dependent protease La (LON)
      cd15777
      Location:241 → 336
      CRBN_C_like; Thalidomide-binding C-terminal domain of cereblon (CRBN) and similar protein domains
      cl19481
      Location:132 → 234
      LON; Found in ATP-dependent protease La (LON)

    2. NM_069899.4 → NP_502300.2  CULT domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502300.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21558
      Conserved Domains (2) summary
      smart00464
      Location:60 → 138
      LON; Found in ATP-dependent protease La (LON)
      cd15777
      Location:277 → 372
      CRBN_C_like; Thalidomide-binding C-terminal domain of cereblon (CRBN) and similar protein domains
    Nucleotide Protein
    Heading Accession and Version

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