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    Y34B4A.4 Rap guanine nucleotide exchange factor 1;Ras-GEF domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180798, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Y34B4A.4
    Official Full Name
    Rap guanine nucleotide exchange factor 1;Ras-GEF domain-containing protein
    Primary source
    WormBase:WBGene00021320
    Locus tag
    CELE_Y34B4A.4
    See related
    AllianceGenome:WB:WBGene00021320
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction. Predicted to be active in plasma membrane. Orthologous to human RAPGEF1 (Rap guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Y34B4A.4 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    19
    Sequence:
    Chromosome: X; NC_003284.9 (5264326..5271800)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Rho-GAP domain-containing protein Neighboring gene ncRNA Neighboring gene Heparan-sulfate 6-O-sulfotransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    2. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Rap guanine nucleotide exchange factor 1;Ras-GEF domain-containing protein
    NP_001024958.1
    • Confirmed by transcript evidence
    NP_001024959.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      5264326..5271800
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029787.4 → NP_001024958.1  Rap guanine nucleotide exchange factor 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024958.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KZX7
      Conserved Domains (2) summary
      cd06224
      Location:499 → 612
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      pfam00617
      Location:640 → 818
      RasGEF; RasGEF domain

    2. NM_001029788.4 → NP_001024959.1  Ras-GEF domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024959.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86MI5
      Conserved Domains (2) summary
      cd06224
      Location:499 → 612
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      pfam00617
      Location:640 → 818
      RasGEF; RasGEF domain
    Nucleotide Protein
    Heading Accession and Version

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