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    jmjd-1.2 JmjC domain-containing protein;Lysine-specific demethylase 7 homolog [ Caenorhabditis elegans ]

    Gene ID: 177232, updated on 9-Dec-2024

    Summary

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    Official Symbol
    jmjd-1.2
    Official Full Name
    JmjC domain-containing protein;Lysine-specific demethylase 7 homolog
    Primary source
    WormBase:WBGene00017920
    Locus tag
    CELE_F29B9.2
    See related
    AllianceGenome:WB:WBGene00017920
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables histone H3K27me2/H3K27me3 demethylase activity; histone H3K9 demethylase activity; and histone binding activity. Involved in mitochondrial unfolded protein response. Located in nucleus. Is expressed in several structures, including germ cell; hypodermis; intestine; muscle cell; and neurons. Used to study syndromic X-linked intellectual disability. Human ortholog(s) of this gene implicated in melanoma and syndromic X-linked intellectual disability Siderius type. Orthologous to several human genes including KDM7A (lysine demethylase 7A). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See jmjd-1.2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    11
    Sequence:
    Chromosome: IV; NC_003282.8 (4660991..4665212)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Mitochondrial Ribosomal Protein, Small Neighboring gene Cytochrome c oxidase polypeptide VIIc Neighboring gene Protein-lysine N-methyltransferase CELE_F29B9.1 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. JMJD-1.2 controls multiple histone post-translational modifications in germ cells and protects the genome from replication stress. Myers TR, et al. Sci Rep, 2018 Feb 28. PMID 29491442, Free PMC Article
    2. Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans. Yang Y, et al. Cell Res, 2010 Aug. PMID 20567261
    3. Coordinated regulation of active and repressive histone methylations by a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans. Lin H, et al. Cell Res, 2010 Aug. PMID 20567262
    4. Identification of family determining residues in Jumonji-C lysine demethylases: A sequence-based, family wide classification. Slama P. Proteins, 2016 Mar. PMID 26757344, Free PMC Article
    5. JMJD-1.2/PHF8 controls axon guidance by regulating Hedgehog-like signaling. Riveiro AR, et al. Development, 2017 Mar 1. PMID 28126843

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. a role for jmjd-1.2 in the maintenance of genome integrity after replication stress
      Title: JMJD-1.2 controls multiple histone post-translational modifications in germ cells and protects the genome from replication stress.
    2. jmjd-1.2 has a role in axon guidance that might be relevant for the onset of X-linked mental retardation
      Title: JMJD-1.2/PHF8 controls axon guidance by regulating Hedgehog-like signaling.
    3. Study demonstrates that both jmjd-1.2 and jmjd-3.1 are necessary and sufficient for activation of the UPRmt in C. elegans and identifies jmjd-1.2 and jmjd-3.1 as positive regulators of a longevity response that genetically requires UPRmt signaling.
      Title: Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K27me2/H3K27me3 demethylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H3K27me2/H3K27me3 demethylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables histone H3K9 demethylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H3K9 demethylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone demethylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial unfolded protein response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    JmjC domain-containing protein;Lysine-specific demethylase 7 homolog
    NP_001294381.1
    • Confirmed by transcript evidence
    NP_500610.1
    • Confirmed by transcript evidence
    NP_500611.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      4660991..4665212
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068209.7 → NP_500610.1  Lysine-specific demethylase 7 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500610.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9BI67, Q9GYI0
      Conserved Domains (2) summary
      cd15517
      Location:211 → 287
      PHD_TCF19_like; PHD finger found in Transcription factor 19 (TCF-19), Lysine-specific demethylase KDM5A and KDM5B, and other similar proteins
      cl21464
      Location:495 → 595
      cupin_like; Conserved domain found in cupin and related proteins

    2. NM_068210.5 → NP_500611.1  Lysine-specific demethylase 7 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500611.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9GYI0
      Conserved Domains (2) summary
      cd15517
      Location:198 → 274
      PHD_TCF19_like; PHD finger found in Transcription factor 19 (TCF-19), Lysine-specific demethylase KDM5A and KDM5B, and other similar proteins
      cl21464
      Location:482 → 582
      cupin_like; Conserved domain found in cupin and related proteins

    3. NM_001307452.3 → NP_001294381.1  JmjC domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294381.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PB84
      Conserved Domains (3) summary
      cd15517
      Location:230 → 306
      PHD_TCF19_like; PHD finger found in Transcription factor 19 (TCF-19), Lysine-specific demethylase KDM5A and KDM5B, and other similar proteins
      pfam17811
      Location:619 → 705
      JHD; Jumonji helical domain
      cl21464
      Location:514 → 614
      cupin_like; Conserved domain found in cupin and related proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9GYI0.1

    Gene LinkOut

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