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    eif-3.I Eukaryotic translation initiation factor 3 subunit I;Serine-threonine kinase receptor-associated protein [ Caenorhabditis elegans ]

    Gene ID: 171809, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eif-3.I
    Official Full Name
    Eukaryotic translation initiation factor 3 subunit I;Serine-threonine kinase receptor-associated protein
    Primary source
    WormBase:WBGene00001232
    Locus tag
    CELE_Y74C10AR.1
    See related
    AllianceGenome:WB:WBGene00001232
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA binding activity and translation initiation factor activity. Predicted to be involved in cytoplasmic translational initiation. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 3 complex, eIF3m. Orthologous to human EIF3I (eukaryotic translation initiation factor 3 subunit I). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See eif-3.I in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003279.8 (2485861..2489787)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Transmembrane protein 50A Neighboring gene ABC transmembrane type-1 domain-containing protein;Iron-sulfur clusters transporter ABCB7, mitochondrial Neighboring gene Conserved secreted protein Neighboring gene ATP-dependent RNA helicase;ATP-dependent rRNA helicase SPB4-like C-terminal extension domain-containing protein Neighboring gene U3 small nucleolar RNA-associated protein 15 homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. HRDE-2 drives small RNA specificity for the nuclear Argonaute protein HRDE-1. Chen S, et al. Nat Commun, 2024 Feb 1. PMID 38302462, Free PMC Article
    2. A complex containing the O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 regulates GABA neuron function. Giles AC, et al. J Biol Chem, 2019 Apr 26. PMID 30858176, Free PMC Article
    3. Functional characterization of C. elegans Y-box-binding proteins reveals tissue-specific functions and a critical role in the formation of polysomes. Arnold A, et al. Nucleic Acids Res, 2014 Dec 1. PMID 25378320, Free PMC Article
    4. Mechanism and regulation of translation in C. elegans. Rhoads RE, et al. WormBook, 2006 Jan 28. PMID 18050488, Free PMC Article
    5. Caenorhabditis elegans ALG-1 antimorphic mutations uncover functions for Argonaute in microRNA guide strand selection and passenger strand disposal. Zinovyeva AY, et al. Proc Natl Acad Sci U S A, 2015 Sep 22. PMID 26351692, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in formation of cytoplasmic translation initiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic 43S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic 48S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex, eIF3m IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Eukaryotic translation initiation factor 3 subunit I;Serine-threonine kinase receptor-associated protein
    NP_001293284.1
    • Confirmed by transcript evidence
    NP_490988.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      2485861..2489787
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058587.6 → NP_490988.2  Eukaryotic translation initiation factor 3 subunit I [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490988.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q965S8
      Conserved Domains (3) summary
      COG2319
      Location:5 → 313
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:14 → 50
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:6 → 313
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001306355.3 → NP_001293284.1  Serine-threonine kinase receptor-associated protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293284.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061ADR6
      Conserved Domains (2) summary
      smart00320
      Location:24 → 59
      WD40; WD40 repeats
      sd00039
      Location:36 → 62
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q965S8.2

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