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    srrt-1 Serrate RNA effector molecule homolog [ Caenorhabditis elegans ]

    Gene ID: 171996, updated on 9-Dec-2024

    Summary

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    Official Symbol
    srrt-1
    Official Full Name
    Serrate RNA effector molecule homolog
    Primary source
    WormBase:WBGene00017085
    Locus tag
    CELE_E01A2.2
    See related
    AllianceGenome:WB:WBGene00017085
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in primary miRNA processing. Predicted to be located in nucleoplasm. Predicted to be active in nuclear body. Orthologous to human SRRT (serrate, RNA effector molecule). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See srrt-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (4132500..4135239)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Abnormal cell lineage protein 44 Neighboring gene NF-kappa-B-activating protein C-terminal domain-containing protein Neighboring gene Diphthine--ammonia ligase Neighboring gene Akirin Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CMTR-1 RNA methyltransferase mutations activate widespread expression of a dopaminergic neuron-specific mitochondrial complex I gene. Meisel JD, et al. Curr Biol, 2024 Jun 17. PMID 38810637, Free PMC Article
    2. A novel, essential trans-splicing protein connects the nematode SL1 snRNP to the CBC-ARS2 complex. Fasimoye RY, et al. Nucleic Acids Res, 2022 Jul 22. PMID 35736244, Free PMC Article
    3. The Helicase Aquarius/EMB-4 Is Required to Overcome Intronic Barriers to Allow Nuclear RNAi Pathways to Heritably Silence Transcription. Akay A, et al. Dev Cell, 2017 Aug 7. PMID 28787591, Free PMC Article
    4. A human protein interaction network shows conservation of aging processes between human and invertebrate species. Bell R, et al. PLoS Genet, 2009 Mar. PMID 19293945, Free PMC Article
    5. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in primary miRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in primary miRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulatory ncRNA-mediated gene silencing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nuclear body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Serrate RNA effector molecule homolog
    NP_001379849.1
    • Confirmed by transcript evidence
    NP_491302.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      4132500..4135239
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058901.5 → NP_491302.1  Serrate RNA effector molecule homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491302.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86S87, Q966L5
      Conserved Domains (2) summary
      pfam04959
      Location:497 → 634
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:88 → 197
      DUF3546; Domain of unknown function (DUF3546)

    2. NM_001392096.1 → NP_001379849.1  Serrate RNA effector molecule homolog [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      pfam04959
      Location:314 → 450
      ARS2; Arsenite-resistance protein 2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q966L5.1

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