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    • Showing Current items.

    efn-4 Ephrin-4 [ Caenorhabditis elegans ]

    Gene ID: 176882, updated on 9-Dec-2024

    Summary

    Official Symbol
    efn-4
    Official Full Name
    Ephrin-4
    Primary source
    WormBase:WBGene00001165
    Locus tag
    CELE_F56A11.3
    See related
    AllianceGenome:WB:WBGene00001165
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ephrin receptor binding activity. Involved in several processes, including embryonic morphogenesis; nematode male tail tip morphogenesis; and regulation of axon guidance. Located in axon and neuronal cell body. Is expressed in several structures, including CAN; epithelial cell; ganglia; intestinal cell; and somatic nervous system. Human ortholog(s) of this gene implicated in craniofrontonasal syndrome and dysostosis. Orthologous to several human genes including EFNB1 (ephrin B1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See efn-4 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (559234..568147)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene MOSC domain-containing protein Neighboring gene Cytoplasmic FMR1-interacting protein homolog Neighboring gene Uncharacterized protein

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ephrin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell migration involved in gastrulation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cell migration involved in gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in embryo development ending in birth or egg hatching IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ephrin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in morphogenesis of embryonic epithelium IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in morphogenesis of embryonic epithelium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nematode male tail tip morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in nematode male tail tip morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of axon guidance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell adhesion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Ephrin-4
    NP_499947.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      559234..568147
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067546.6NP_499947.1  Ephrin-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499947.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O44516
      Conserved Domains (1) summary
      cd02675
      Location:23179
      Ephrin_ectodomain; Ectodomain of Ephrins