scp-1 Sterol regulatory element-binding protein cleavage-activating protein;WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: scp-1
Official Full Name: Sterol regulatory element-binding protein cleavage-activating protein;WD_REPEATS_REGION domain-containing protein
Primary source: WormBase:WBGene00004744
Locus tag: CELE_D2013.8
See related: AllianceGenome:WB:WBGene00004744
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable sterol binding activity. Predicted to be involved in regulation of cholesterol biosynthetic process. Predicted to be located in ER to Golgi transport vesicle membrane; Golgi membrane; and endoplasmic reticulum. Predicted to be part of SREBP-SCAP complex. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human SCAP (SREBF chaperone). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See scp-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 12

Sequence:: Chromosome: II; NC_003280.10 (9334014..9338896)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

sterol regulatory element-binding protein (SREBP) and mediator-15 (MDT-15) prevent the life-shortening effects of a glucose-rich diet by regulating fat-converting processes in Caenorhabditis elegans
Title: SREBP and MDT-15 protect C. elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat.

Submit: New GeneRIF Correction

General gene information

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Markers

STS2-174 (e-PCR)
- UniSTS:241845

D2013.8 (e-PCR)
- UniSTS:309478

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables sterol binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in SREBP signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cholesterol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of cholesterol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to stimulus	IEA Inferred from Electronic Annotation more info
involved_in steroid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in ER to Golgi transport vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
part_of SREBP-SCAP complex	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Sterol regulatory element-binding protein cleavage-activating protein;WD_REPEATS_REGION domain-containing protein

NP_001022051.1

Confirmed by transcript evidence

NP_001370189.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

9334014..9338896

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001026880.6 → NP_001022051.1 Sterol regulatory element-binding protein cleavage-activating protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022051.1

Status: REVIEWED

UniProtKB/TrEMBL

Q18968

Conserved Domains (4) summary

COG2319
Location:727 → 1043

WD40; WD40 repeat [General function prediction only]

pfam12349
Location:295 → 448

Sterol-sensing; Sterol-sensing domain of SREBP cleavage-activation

sd00039
Location:735 → 770

7WD40; WD40 repeat [structural motif]

cl02567
Location:727 → 959

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001383916.2 → NP_001370189.1 WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q5FC80

Conserved Domains (3) summary

COG2319
Location:183 → 415

WD40; WD40 repeat [General function prediction only]

sd00039
Location:73 → 108

7WD40; WD40 repeat [structural motif]

cl29593
Location:65 → 297

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...