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    zer-1 Zyg eleven-related protein 1 [ Caenorhabditis elegans ]

    Gene ID: 175249, updated on 9-Dec-2024

    Summary

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    Official Symbol
    zer-1
    Official Full Name
    Zyg eleven-related protein 1
    Primary source
    WormBase:WBGene00020762
    Locus tag
    CELE_T24C4.6
    See related
    AllianceGenome:WB:WBGene00020762
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Part of Cul2-RING ubiquitin ligase complex. Orthologous to human ZER1 (zyg-11 related cell cycle regulator). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See zer-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (881443..886789, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene DUF2975 domain-containing protein Neighboring gene Transmembrane protein 225 Neighboring gene DNA primase Neighboring gene Peptidase M16 N-terminal domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene C2H2-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A CUL-2 ubiquitin ligase containing three FEM proteins degrades TRA-1 to regulate C. elegans sex determination. Starostina NG, et al. Dev Cell, 2007 Jul. PMID 17609115, Free PMC Article
    2. The Caenorhabditis elegans cell-cycle regulator ZYG-11 defines a conserved family of CUL-2 complex components. Vasudevan S, et al. EMBO Rep, 2007 Mar. PMID 17304241, Free PMC Article
    3. Overcoming redundancy: an RNAi enhancer screen for morphogenesis genes in Caenorhabditis elegans. Sawyer JM, et al. Genetics, 2011 Jul. PMID 21527776, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul2-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Cul2-RING ubiquitin ligase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of Cul2-RING ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Zyg eleven-related protein 1
    NP_741089.2
    • Confirmed by transcript evidence
    NP_741090.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      881443..886789 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171078.7 → NP_741089.2  Zyg eleven-related protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741089.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q2WF58, Q2WF59
      Conserved Domains (1) summary
      sd00034
      Location:98 → 123
      LRR_AMN1; leucine-rich repeat [structural motif]

    2. NM_171079.10 → NP_741090.3  Zyg eleven-related protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741090.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q2WF59
      Conserved Domains (2) summary
      cd00020
      Location:594 → 720
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00034
      Location:98 → 123
      LRR_AMN1; leucine-rich repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2WF59.1

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