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    fbxl-1 F-box/LRR-repeat protein fbxl-1 [ Caenorhabditis elegans ]

    Gene ID: 3564805, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fbxl-1
    Official Full Name
    F-box/LRR-repeat protein fbxl-1
    Primary source
    WormBase:WBGene00015350
    Locus tag
    CELE_C02F5.7
    See related
    AllianceGenome:WB:WBGene00015350
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in several processes, including dauer entry; defecation rhythm; and regulation of defecation rhythm. Located in several cellular components, including axon; dendrite; and perikaryon. Orthologous to human FBXL2 (F-box and leucine rich repeat protein 2) and FBXL20 (F-box and leucine rich repeat protein 20). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See fbxl-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (8227830..8232660)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene MOB-like protein phocein Neighboring gene RAD51-like protein 1 Neighboring gene ncRNA Neighboring gene Small RNA 2'-O-methyltransferase Neighboring gene MBL fold metallo-hydrolase Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dichloroacetate improves mitochondrial function, physiology, and morphology in FBXL4 disease models. Lavorato M, et al. JCI Insight, 2022 Aug 22. PMID 35881484, Free PMC Article
    2. CFL-1, a novel F-box protein with leucine-rich repeat may interact with UNC-10 for the regulation of defecation and daumone response in Caenorhabditis elegans. Kim SM, et al. Anim Cells Syst (Seoul), 2017. PMID 30460068, Free PMC Article
    3. Multiple Skp1-related proteins in Caenorhabditis elegans: diverse patterns of interaction with Cullins and F-box proteins. Yamanaka A, et al. Curr Biol, 2002 Feb 19. PMID 11864566
    4. An integrated strategy to study muscle development and myofilament structure in Caenorhabditis elegans. Meissner B, et al. PLoS Genet, 2009 Jun. PMID 19557190, Free PMC Article
    5. The F-box protein family. Kipreos ET, et al. Genome Biol, 2000. PMID 11178263, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dauer entry IMP
    Inferred from Mutant Phenotype
    more info
    		  
    involved_in defecation rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		  
    involved_in regulation of dauer entry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of defecation rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		  
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perikaryon IDA
    Inferred from Direct Assay
    more info
    		  
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    F-box/LRR-repeat protein fbxl-1
    NP_001379603.1
    • Confirmed by transcript evidence
    NP_741248.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      8227830..8232660
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171210.8 → NP_741248.1  F-box/LRR-repeat protein fbxl-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741248.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34284, Q8T3G0
      Conserved Domains (3) summary
      cd09293
      Location:121 → 268
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:125 → 150
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:60 → 101
      F-box-like

    2. NM_001392151.1 → NP_001379603.1  F-box/LRR-repeat protein fbxl-1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (3) summary
      cd09293
      Location:121 → 268
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:125 → 150
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:60 → 101
      F-box-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34284.3

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