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    lec-3 32 kDa beta-galactoside-binding lectin lec-3;Galectin;gaLECtin [ Caenorhabditis elegans ]

    Gene ID: 174557, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lec-3
    Official Full Name
    32 kDa beta-galactoside-binding lectin lec-3;Galectin;gaLECtin
    Primary source
    WormBase:WBGene00002266
    Locus tag
    CELE_ZK892.1
    See related
    AllianceGenome:WB:WBGene00002266
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable carbohydrate binding activity and galactoside binding activity. Located in plasma membrane. Orthologous to several human genes including LGALS9 (galectin 9) and LGALS9B (galectin 9B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lec-3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    14
    Sequence:
    Chromosome: II; NC_003280.10 (9991160..10000350)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene C2H2-type domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Non-specific lipid-transfer protein-like 1 Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caenorhabditis elegans galectins LEC-1-LEC-11: structural features and sugar-binding properties. Nemoto-Sasaki Y, et al. Biochim Biophys Acta, 2008 Oct. PMID 18675319
    2. A Caenorhabditis elegans glycolipid-binding galectin functions in host defense against bacterial infection. Ideo H, et al. J Biol Chem, 2009 Sep 25. PMID 19635802, Free PMC Article
    3. General and cell-type specific mechanisms target TRPP2/PKD-2 to cilia. Bae YK, et al. Development, 2006 Oct. PMID 16943275
    4. Galectin LEC-1 plays a defensive role against damage due to oxidative stress in Caenorhabditis elegans. Takeuchi T, et al. J Biochem, 2013 Nov. PMID 23935187
    5. SAFER, an Analysis Method of Quantitative Proteomic Data, Reveals New Interactors of the C. elegans Autophagic Protein LGG-1. Yi Z, et al. J Proteome Res, 2016 May 6. PMID 26999449

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables carbohydrate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables galactoside binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    32 kDa beta-galactoside-binding lectin lec-3;Galectin;gaLECtin
    NP_001022531.1
    • Confirmed by transcript evidence
    NP_001022532.1
    • Partially confirmed by transcript evidence
    NP_001022533.1
    • Partially confirmed by transcript evidence
    NP_001022534.1
    • Product from WormBase gene class lec;
      Confirmed by transcript evidence
    NP_001263668.1
    • Confirmed by transcript evidence
    NP_496159.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      9991160..10000350
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276739.3 → NP_001263668.1  Galectin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263668.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      I2HAG1
      Conserved Domains (1) summary
      cd00070
      Location:198 → 328
      GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...

    2. NM_001027360.6 → NP_001022531.1  Galectin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022531.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95ZI4
      Conserved Domains (1) summary
      cd00070
      Location:158 → 276
      GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...

    3. NM_063758.9 → NP_496159.1  32 kDa beta-galactoside-binding lectin lec-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496159.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09581, Q9GNP6
      Conserved Domains (1) summary
      cd00070
      Location:158 → 288
      GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...

    4. NM_001027361.4 → NP_001022532.1  Galectin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022532.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I4A5
      Conserved Domains (2) summary
      cd00070
      Location:14 → 144
      GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...
      cl00071
      Location:162 → 205
      GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...

    5. NM_001027362.7 → NP_001022533.1  Galectin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022533.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I4A4
      Conserved Domains (1) summary
      cd00070
      Location:162 → 303
      GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...

    6. NM_001027363.5 → NP_001022534.1  gaLECtin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022534.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I4A3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09581.3

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