U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    riok-3 Serine/threonine-protein kinase RIO3 [ Caenorhabditis elegans ]

    Gene ID: 176387, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    riok-3
    Official Full Name
    Serine/threonine-protein kinase RIO3
    Primary source
    WormBase:WBGene00014012
    Locus tag
    CELE_ZK632.3
    See related
    AllianceGenome:WB:WBGene00014012
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in maturation of SSU-rRNA. Predicted to be part of preribosome, small subunit precursor. Predicted to be active in cytosol. Is expressed in intestine. Orthologous to human RIOK3 (RIO kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See riok-3 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (9802355..9805011, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene DNA replication licensing factor mcm-6 Neighboring gene Serpentine receptor class XA 10 Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene putative mannose-6-phosphate isomerase

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Flatworms have lost the right open reading frame kinase 3 gene during evolution. Breugelmans B, et al. Sci Rep, 2015 May 15. PMID 25976756, Free PMC Article
    2. Bioinformatic exploration of RIO protein kinases of parasitic and free-living nematodes. Breugelmans B, et al. Int J Parasitol, 2014 Oct 1. PMID 25038443
    3. Atypical (RIO) protein kinases from Haemonchus contortus--promise as new targets for nematocidal drugs. Campbell BE, et al. Biotechnol Adv, 2011 May-Jun. PMID 21262337
    4. Investigating the role of RIO protein kinases in Caenorhabditis elegans. Mendes TK, et al. PLoS One, 2015. PMID 25688864, Free PMC Article
    5. Reference quantitative transcriptome dataset for adult Caenorhabditis elegans. Piovesan A, et al. Data Brief, 2019 Aug. PMID 31440537, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of SSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of preribosome, small subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Serine/threonine-protein kinase RIO3
    NP_499173.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9802355..9805011 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066772.9 → NP_499173.1  Serine/threonine-protein kinase RIO3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499173.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34649
      Conserved Domains (2) summary
      smart00090
      Location:218 → 453
      RIO; RIO-like kinase
      COG1718
      Location:210 → 437
      RIO1; Serine/threonine-protein kinase RIO1 [Signal transduction mechanisms]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34649.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools