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    hlh-31 BHLH domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 3565632, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hlh-31
    Official Full Name
    BHLH domain-containing protein
    Primary source
    WormBase:WBGene00009540
    Locus tag
    CELE_F38C2.8
    See related
    AllianceGenome:WB:WBGene00009540
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity and E-box binding activity. Predicted to be involved in neuron differentiation; positive regulation of transcription by RNA polymerase II; and sensory organ development. Predicted to be active in nucleus. Orthologous to human BHLHE22 (basic helix-loop-helix family member e22). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hlh-31 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    3
    Sequence:
    Chromosome: IV; NC_003282.8 (16257630..16259534)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. mls-2 and vab-3 Control glia development, hlh-17/Olig expression and glia-dependent neurite extension in C. elegans. Yoshimura S, et al. Development, 2008 Jul. PMID 18508862
    2. A multiparameter network reveals extensive divergence between C. elegans bHLH transcription factors. Grove CA, et al. Cell, 2009 Jul 23. PMID 19632181, Free PMC Article
    3. Transcriptional regulation. Okkema PG, et al. WormBook, 2005 Dec 23. PMID 18050428, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables E-box binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    BHLH domain-containing protein
    NP_001023193.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      16257630..16259534
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001028022.3 → NP_001023193.2  BHLH domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023193.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86D08
      Conserved Domains (1) summary
      cl00081
      Location:78 → 137
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
    Nucleotide Protein
    Heading Accession and Version

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