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    • Showing Current items.

    nlp-29 QWGYGGY-amide [ Caenorhabditis elegans ]

    Gene ID: 178805, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nlp-29
    Official Full Name
    QWGYGGY-amide
    Primary source
    WormBase:WBGene00003767
    Locus tag
    CELE_B0213.4
    See related
    AllianceGenome:WB:WBGene00003767
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable neuropeptide receptor binding activity. Predicted to be involved in defense response to other organism; killing of cells of another organism; and neuropeptide signaling pathway. Predicted to be located in extracellular space. Is expressed in hypodermis and intestine. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nlp-29 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    2
    Sequence:
    Chromosome: V; NC_003283.11 (3984425..3984847)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene QWGYGGY-amide Neighboring gene QWGYGGY-amide Neighboring gene QWGYGGY-amide Neighboring gene Neuropeptide-Like Protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Virulence of Leucobacter chromiireducens subsp. solipictus to Caenorhabditis elegans: characterization of a novel host-pathogen interaction. Muir RE, et al. Appl Environ Microbiol, 2008 Jul. PMID 18487405, Free PMC Article
    2. Fabrication of sharp silicon arrays to wound Caenorhabditis elegans. Belougne J, et al. Sci Rep, 2020 Feb 27. PMID 32108170, Free PMC Article
    3. An Antimicrobial Peptide and Its Neuronal Receptor Regulate Dendrite Degeneration in Aging and Infection. E L, et al. Neuron, 2018 Jan 3. PMID 29301098, Free PMC Article
    4. RACK-1, a multifaceted regulator is required for C. elegans innate immunity against S. flexneri M9OT infection. Marudhupandiyan S, et al. Dev Comp Immunol, 2017 Sep. PMID 28502651
    5. The fatty acid synthase fasn-1 acts upstream of WNK and Ste20/GCK-VI kinases to modulate antimicrobial peptide expression in C. elegans epidermis. Lee KZ, et al. Virulence, 2010 May-Jun. PMID 21178429, Free PMC Article

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The authors demonstrated a specific role for hsp-3 in the regulation of nlp-29 after infection that is not shared with hsp-4.
      Title: A UPR-independent infection-specific role for a BiP/GRP78 protein in the control of antimicrobial peptide expression in C. elegans epidermis.
    2. Fasn-1 regulates antimicrobial peptide nlp-29 expression in a WNK-1 and gck-3 dependent manner.
      Title: The fatty acid synthase fasn-1 acts upstream of WNK and Ste20/GCK-VI kinases to modulate antimicrobial peptide expression in C. elegans epidermis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables neuropeptide receptor binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to bacterium IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defense response to fungus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in killing of cells of another organism IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    QWGYGGY-amide
    NP_504109.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      3984425..3984847
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_071708.6 → NP_504109.1  QWGYGGY-amide [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504109.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O44664
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O44664.1

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