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    apg-1 AP-1 complex subunit gamma [ Caenorhabditis elegans ]

    Gene ID: 173304, updated on 9-Dec-2024

    Summary

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    Official Symbol
    apg-1
    Official Full Name
    AP-1 complex subunit gamma
    Primary source
    WormBase:WBGene00000158
    Locus tag
    CELE_Y105E8A.9
    See related
    AllianceGenome:WB:WBGene00000158
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable clathrin adaptor activity and clathrin binding activity. Involved in apical protein localization and protein secretion. Predicted to be located in Golgi apparatus; cytoplasmic vesicle; and membrane. Predicted to be part of AP-1 adaptor complex. Orthologous to several human genes including AP1G1 (adaptor related protein complex 1 subunit gamma 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See apg-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    9
    Sequence:
    Chromosome: I; NC_003279.8 (14406028..14417934)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene CUB domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene WD_REPEATS_REGION domain-containing protein Neighboring gene Non-lysosomal glucosylceramidase Neighboring gene BolA-like protein 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AP-1 is required for the maintenance of apico-basal polarity in the C. elegans intestine. Shafaq-Zadah M, et al. Development, 2012 Jun. PMID 22535414
    2. Clathrin and AP-1 regulate apical polarity and lumen formation during C. elegans tubulogenesis. Zhang H, et al. Development, 2012 Jun. PMID 22535410, Free PMC Article
    3. Clathrin interaction and subcellular localization of Ce-DAB-1, an adaptor for protein secretion in Caenorhabditis elegans. Kamikura DM, et al. Traffic, 2006 Mar. PMID 16497226
    4. Control of E-cadherin apical localisation and morphogenesis by a SOAP-1/AP-1/clathrin pathway in C. elegans epidermal cells. Gillard G, et al. Development, 2015 May 1. PMID 25858456
    5. AP-1 Recruits SMAP-1/SMAPs to the trans-Golgi Network to Promote Sorting in Polarized Epithelia. Wang S, et al. Front Cell Dev Biol, 2021. PMID 34901019, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The clathrin adaptor protein AP-1 is required for the maintenance of apico-basal polarity in the C. elegans intestine.
      Title: AP-1 is required for the maintenance of apico-basal polarity in the C. elegans intestine.
    2. Clathrin and AP-1 regulate apical polarity and lumen formation during C. elegans tubulogenesis.
      Title: Clathrin and AP-1 regulate apical polarity and lumen formation during C. elegans tubulogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables clathrin adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables clathrin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to vacuole transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in apical protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of AP-1 adaptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of AP-1 adaptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of AP-1 adaptor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of membrane coat IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    AP-1 complex subunit gamma
    NP_740937.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      14406028..14417934
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170941.8 → NP_740937.1  AP-1 complex subunit gamma [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740937.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8WQB3
      Conserved Domains (2) summary
      smart00809
      Location:721 → 827
      Alpha_adaptinC2; Adaptin C-terminal domain
      pfam01602
      Location:45 → 595
      Adaptin_N; Adaptin N terminal region
    Nucleotide Protein
    Heading Accession and Version

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