hda-1 Histone deacetylase 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: hda-1
Official Full Name: Histone deacetylase 1
Primary source: WormBase:WBGene00001834
Locus tag: CELE_C53A5.3
See related: AllianceGenome:WB:WBGene00001834
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and histone deacetylase activity. Contributes to transcription corepressor activity. Involved in several processes, including negative regulation of signal transduction; negative regulation of stress response to copper ion; and regulation of transcription by RNA polymerase II. Acts upstream of or within chromatin organization; determination of adult lifespan; and mitochondrial unfolded protein response. Located in chromatin; cytoplasm; and germ cell nucleus. Part of NuRD complex. Is expressed in several structures, including anchor cell; germ line; hypodermis; nervous system; and vulva. Human ortholog(s) of this gene implicated in stomach cancer. Orthologous to human HDAC1 (histone deacetylase 1) and HDAC2 (histone deacetylase 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See hda-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 4

Sequence:: Chromosome: V; NC_003283.11 (14525389..14527411)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The chromatin factors SET-26 and HCF-1 oppose the histone deacetylase HDA-1 in longevity and gene regulation in C. elegans.
Title: The chromatin factors SET-26 and HCF-1 oppose the histone deacetylase HDA-1 in longevity and gene regulation in C. elegans.
HDAC1 SUMOylation promotes Argonaute-directed transcriptional silencing in C. elegans.
Title: HDAC1 SUMOylation promotes Argonaute-directed transcriptional silencing in C. elegans.
Inactivating histone deacetylase HDA promotes longevity by mobilizing trehalose metabolism.
Title: Inactivating histone deacetylase HDA promotes longevity by mobilizing trehalose metabolism.
Histone deacetylase HDA-1 modulates mitochondrial stress response and longevity.
Title: Histone deacetylase HDA-1 modulates mitochondrial stress response and longevity.
We further show that G1 arrest is necessary for the histone deacetylase HDA-1, a key regulator of differentiation, to promote pro-invasive gene expression and invadopodia formation.
Title: Invasive Cell Fate Requires G1 Cell-Cycle Arrest and Histone Deacetylase-Mediated Changes in Gene Expression.
hda-1 target genes revealed that fos-1 acts downstream of hda-1 in vulval cells, whereas egl-43 and nhr-67 mediate hda-1 function in the gonadal anchor cell.
Title: Caenorhabditis elegans histone deacetylase hda-1 is required for morphogenesis of the vulva and LIN-12/Notch-mediated specification of uterine cell fates.
HDAC behaves as a co-repressor modulating FOS-1-mediated transcriptional regulation
Title: The Caenorhabditis elegans JNK signaling pathway activates expression of stress response genes by derepressing the Fos/HDAC repressor complex.
Theses studies define a new role for HDA-1 in nervous system development, and provide the first evidence for HDAC function in regulating neuronal axon guidance.
Title: The C. elegans histone deacetylase HDA-1 is required for cell migration and axon pathfinding.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C53A5.1 (e-PCR)
- UniSTS:316420

C53A5.3 (e-PCR)
- UniSTS:307376

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables histone deacetylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone deacetylase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone deacetylase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to transcription corepressor activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromatin organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic digestive tract morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hermaphrodite somatic sex determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitochondrial unfolded protein response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Ras protein signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of stress response to copper ion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of vulval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of vulval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode male tail tip morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of NuRD complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NuRD complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of NuRD complex	IPI Inferred from Physical Interaction more info	PubMed
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of histone deacetylase complex	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: Histone deacetylase 1

NP_506599.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

14525389..14527411

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_074198.10 → NP_506599.1 Histone deacetylase 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_506599.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O17695

Conserved Domains (1) summary

cd09991
Location:18 → 323

HDAC_classI; Class I histone deacetylases