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    ttm-1 Zinc transporter ttm-1 [ Caenorhabditis elegans ]

    Gene ID: 176715, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ttm-1
    Official Full Name
    Zinc transporter ttm-1
    Primary source
    WormBase:WBGene00012712
    Locus tag
    CELE_Y39E4A.2
    See related
    AllianceGenome:WB:WBGene00012712
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable zinc ion transmembrane transporter activity. Involved in response to cadmium ion and response to nematicide. Predicted to be located in apical plasma membrane and cytoplasmic vesicle membrane. Predicted to be active in plasma membrane. Is expressed in head neurons; hypodermis; intestine; and vulva. Orthologous to human SLC30A3 (solute carrier family 30 member 3) and SLC30A4 (solute carrier family 30 member 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ttm-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (12952969..12966995, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Glutamate decarboxylase;Glutamate decarboxylase 1 Neighboring gene Uncharacterized protein Neighboring gene 2-oxoisovalerate dehydrogenase subunit alpha;2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial Neighboring gene DUF155 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Zinc oxide/graphene oxide nanocomposites specifically remediated Cd-contaminated soil via reduction of bioavailability and ecotoxicity of Cd. Li Y, et al. Sci Total Environ, 2024 Aug 25. PMID 38825205
    2. ttm-1 encodes CDF transporters that excrete zinc from intestinal cells of C. elegans and act in a parallel negative feedback circuit that promotes homeostasis. Roh HC, et al. PLoS Genet, 2013 May. PMID 23717214, Free PMC Article
    3. SLC30A10: A novel manganese transporter. Chen P, et al. Worm, 2015 Jul-Sep. PMID 26430566, Free PMC Article
    4. A modular system of DNA enhancer elements mediates tissue-specific activation of transcription by high dietary zinc in C. elegans. Roh HC, et al. Nucleic Acids Res, 2015 Jan. PMID 25552416, Free PMC Article
    5. Mitogen-activated protein kinase pathways defend against bacterial pore-forming toxins. Huffman DL, et al. Proc Natl Acad Sci U S A, 2004 Jul 27. PMID 15256590, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We showed that TTM-1 isoforms function in tandem with CDF-2, which is also induced by high levels of cytoplasmic zinc and reduces cytoplasmic zinc levels by sequestering zinc in lysosome-related organelles
      Title: ttm-1 encodes CDF transporters that excrete zinc from intestinal cells of C. elegans and act in a parallel negative feedback circuit that promotes homeostasis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables monoatomic cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic cation transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to cadmium ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to nematicide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to zinc ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in zinc ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in zinc ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Zinc transporter ttm-1
    NP_001299904.1
    • Confirmed by transcript evidence
    NP_499691.1
    • Confirmed by transcript evidence
    NP_499692.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      12952969..12966995 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067291.8 → NP_499692.1  Zinc transporter ttm-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499692.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0K3AU82, O45922, O45923
      Conserved Domains (1) summary
      TIGR01297
      Location:114 → 393
      CDF; cation diffusion facilitator family transporter

    2. NM_067290.6 → NP_499691.1  Zinc transporter ttm-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499691.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O45922
      Conserved Domains (1) summary
      TIGR01297
      Location:95 → 374
      CDF; cation diffusion facilitator family transporter

    3. NM_001312975.3 → NP_001299904.1  Zinc transporter ttm-1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AU82
      Conserved Domains (1) summary
      TIGR01297
      Location:37 → 316
      CDF; cation diffusion facilitator family transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O45923.1

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