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    ash-2 B30.2/SPRY domain-containing protein;Set1/Ash2 histone methyltransferase complex subunit ash-2 [ Caenorhabditis elegans ]

    Gene ID: 174838, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ash-2
    Official Full Name
    B30.2/SPRY domain-containing protein;Set1/Ash2 histone methyltransferase complex subunit ash-2
    Primary source
    WormBase:WBGene00012458
    Locus tag
    CELE_Y17G7B.2
    See related
    AllianceGenome:WB:WBGene00012458
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable transcription cis-regulatory region binding activity. Involved in determination of adult lifespan; programmed cell death; and transdifferentiation. Located in nucleus. Part of MLL3/4 complex. Is expressed in germ line. Orthologous to human ASH2L (ASH2 like, histone lysine methyltransferase complex subunit). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ash-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    11
    Sequence:
    Chromosome: II; NC_003280.10 (11979838..11989050)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene BZIP domain-containing protein;Regulator of rDNA transcription 14 Neighboring gene BZIP domain-containing protein Neighboring gene hydroxyacylglutathione hydrolase Neighboring gene Deoxyhypusine synthase Neighboring gene Activin_recp domain-containing protein;DUF281 domain-containing protein Neighboring gene DNA replication licensing factor MCM2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transgenerational lipid-reducing activity of benzylisoquinoline alkaloids in Caenorhabditis elegans. Chow YL, et al. Genes Cells, 2019 Jan. PMID 30451341
    2. Intestine-to-Germline Transmission of Epigenetic Information Intergenerationally Ensures Systemic Stress Resistance in C. elegans. Nono M, et al. Cell Rep, 2020 Mar 10. PMID 32160530
    3. Loss of the histone chaperone UNC-85/ASF1 inhibits the epigenome-mediated longevity and modulates the activity of one-carbon metabolism. Shrestha B, et al. Cell Stress Chaperones, 2024 Jun. PMID 38608859, Free PMC Article
    4. Caenorhabditis elegans chromatin-associated proteins SET-2 and ASH-2 are differentially required for histone H3 Lys 4 methylation in embryos and adult germ cells. Xiao Y, et al. Proc Natl Acad Sci U S A, 2011 May 17. PMID 21527717, Free PMC Article
    5. The SET-2/SET1 histone H3K4 methyltransferase maintains pluripotency in the Caenorhabditis elegans germline. Robert VJ, et al. Cell Rep, 2014 Oct 23. PMID 25310986

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In AIB interneurons, NPR-4 was involved in the control of preference choice by activating the functions of ASH-2 trithorax complex consisting of SET-2, ASH-2, and WDR-5, implying the crucial role of molecular machinery of trimethylation of histone H3K4 in the preference choice control.
      Title: FLP-4 neuropeptide and its receptor in a neuronal circuit regulate preference choice through functions of ASH-2 trithorax complex in Caenorhabditis elegans.
    2. SET-2 is responsible for the majority of bulk H3K4 methylation at all developmental stages
      Title: Caenorhabditis elegans chromatin-associated proteins SET-2 and ASH-2 are differentially required for histone H3 Lys 4 methylation in embryos and adult germ cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transdifferentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MLL3/4 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Set1C/COMPASS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Set1C/COMPASS complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    B30.2/SPRY domain-containing protein;Set1/Ash2 histone methyltransferase complex subunit ash-2
    NP_001317781.1
    • Confirmed by transcript evidence
    NP_001359515.1
    • Confirmed by transcript evidence
    NP_001360415.1
    • Confirmed by transcript evidence
    NP_496555.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      11979838..11989050
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001373799.3 → NP_001359515.1  B30.2/SPRY domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XXH4
      Conserved Domains (3) summary
      cd15583
      Location:21 → 75
      PHD_ash2p_like; PHD finger found in Schizosaccharomyces pombe Set1 complex component ash2 (spAsh2p) and similar proteins
      cd12872
      Location:314 → 512
      SPRY_Ash2; SPRY domain in Ash2
      pfam12005
      Location:169 → 221
      DUF3499; Protein of unknown function (DUF3499)

    2. NM_064154.3 → NP_496555.1  Set1/Ash2 histone methyltransferase complex subunit ash-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496555.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EFZ3
      Conserved Domains (2) summary
      cd15583
      Location:21 → 73
      PHD_ash2p_like; PHD finger found in Schizosaccharomyces pombe Set1 complex component ash2 (spAsh2p) and similar proteins
      cd12872
      Location:312 → 510
      SPRY_Ash2; SPRY domain in Ash2

    3. NM_001330962.4 → NP_001317781.1  B30.2/SPRY domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A168H2F9
      Conserved Domains (3) summary
      cd15583
      Location:21 → 73
      PHD_ash2p_like; PHD finger found in Schizosaccharomyces pombe Set1 complex component ash2 (spAsh2p) and similar proteins
      cd12872
      Location:315 → 513
      SPRY_Ash2; SPRY domain in Ash2
      pfam12005
      Location:167 → 219
      DUF3499; Protein of unknown function (DUF3499)

    4. NM_001373798.2 → NP_001360415.1  B30.2/SPRY domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A168H287
      Conserved Domains (3) summary
      cd15583
      Location:21 → 75
      PHD_ash2p_like; PHD finger found in Schizosaccharomyces pombe Set1 complex component ash2 (spAsh2p) and similar proteins
      cd12872
      Location:317 → 515
      SPRY_Ash2; SPRY domain in Ash2
      pfam12005
      Location:169 → 221
      DUF3499; Protein of unknown function (DUF3499)

    RNA

    1. NR_138517.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EFZ3.1

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