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    Cd200r1 CD200 receptor 1 [ Mus musculus (house mouse) ]

    Gene ID: 57781, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cd200r1provided by MGI
    Official Full Name
    CD200 receptor 1provided by MGI
    Primary source
    MGI:MGI:1889024
    See related
    Ensembl:ENSMUSG00000022667 AllianceGenome:MGI:1889024
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    OX2R; Mox2r; CD200R
    Summary
    Enables signaling receptor activity. Predicted to be involved in several processes, including negative regulation of interleukin-6 production; negative regulation of mononuclear cell migration; and negative regulation of neuroinflammatory response. Located in external side of plasma membrane. Is expressed in central nervous system; liver lobe; retina; and thymus primordium. Orthologous to several human genes including CD200R1 (CD200 receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver E18 (RPKM 1.8), liver E14 (RPKM 1.3) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cd200r1 in Genome Data Viewer
    Location:
    16 B4; 16 29.08 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (44586141..44615341)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (44765736..44794977)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30445 Neighboring gene STARR-positive B cell enhancer ABC_E10905 Neighboring gene nucleolus and neural progenitor protein Neighboring gene GTP-binding protein 8 (putative) Neighboring gene STARR-positive B cell enhancer mm9_chr16:44746411-44746712 Neighboring gene STARR-positive B cell enhancer ABC_E5543 Neighboring gene lactate dehydrogenase A pseudogene Neighboring gene synaptotagmin binding, cytoplasmic RNA interacting protein pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CD200R1 regulates eosinophilia during pulmonary fungal infection in mice. Salek-Ardakani S, et al. Eur J Immunol, 2019 Sep. PMID 31365119, Free PMC Article
    2. CD200R signaling inhibits pro-angiogenic gene expression by macrophages and suppresses choroidal neovascularization. Horie S, et al. Sci Rep, 2013 Oct 30. PMID 24170042, Free PMC Article
    3. Upregulation of CD200R1 in lineage-negative leukemic cells is characteristic of AML1-ETO-positive leukemia in mice. Kagiyama Y, et al. Int J Hematol, 2012 Nov. PMID 23097187
    4. CD200 receptor and macrophage function in the intestine. Bain CC, et al. Immunobiology, 2012 Jun. PMID 22204814
    5. CD200-CD200R1 inhibitory signaling prevents spontaneous bacterial infection and promotes resolution of neuroinflammation and recovery after stroke. Ritzel RM, et al. J Neuroinflammation, 2019 Feb 18. PMID 30777093, Free PMC Article

    See all (79) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The regulation of NFKB1 on CD200R1 expression and their potential roles in Parkinson's disease.
      Title: The regulation of NFKB1 on CD200R1 expression and their potential roles in Parkinson's disease.
    2. Activation of the CD200/CD200R1 axis attenuates neuroinflammation and improves postoperative cognitive dysfunction via the PI3K/Akt/NF-kappaB signaling pathway in aged mice.
      Title: Activation of the CD200/CD200R1 axis attenuates neuroinflammation and improves postoperative cognitive dysfunction via the PI3K/Akt/NF-κB signaling pathway in aged mice.
    3. Dysregulated CD200-CD200R signaling in early diabetes modulates microglia-mediated retinopathy.
      Title: Dysregulated CD200-CD200R signaling in early diabetes modulates microglia-mediated retinopathy.
    4. CD200R1 promotes interleukin-17 production by group 3 innate lymphoid cells by enhancing signal transducer and activator of transcription 3 activation.
      Title: CD200R1 promotes interleukin-17 production by group 3 innate lymphoid cells by enhancing signal transducer and activator of transcription 3 activation.
    5. CD200R1 Contributes to Successful Functional Reinnervation after a Sciatic Nerve Injury.
      Title: CD200R1 Contributes to Successful Functional Reinnervation after a Sciatic Nerve Injury.
    6. MicroRNA-129-5p-regulated microglial expression of the surface receptor CD200R1 controls neuroinflammation.
      Title: MicroRNA-129-5p-regulated microglial expression of the surface receptor CD200R1 controls neuroinflammation.
    7. CD200 Immune-Checkpoint Peptide Elicits an Anti-glioma Response Through the DAP10 Signaling Pathway.
      Title: CD200 Immune-Checkpoint Peptide Elicits an Anti-glioma Response Through the DAP10 Signaling Pathway.
    8. The CD200R1 microglial inhibitory receptor as a therapeutic target in the MPTP model of Parkinson's disease.
      Title: The CD200R1 microglial inhibitory receptor as a therapeutic target in the MPTP model of Parkinson's disease.
    9. CD200-CD200R1 signaling pathway regulates neuroinflammation after stroke.
      Title: CD200-CD200R1 signaling pathway regulates neuroinflammation after stroke.
    10. CD200-CD200R immune checkpoint engagement regulates ILC2 effector function and ameliorates lung inflammation in asthma.
      Title: CD200-CD200R immune checkpoint engagement regulates ILC2 effector function and ameliorates lung inflammation in asthma.
    Submit: New GeneRIF Correction See all GeneRIFs (47)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (5)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding involved in heterotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in heterotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of T cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of macrophage migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of neuroinflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neuroinflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of neuroinflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cell surface glycoprotein CD200 receptor 1
    Names
    CD200 cell surface glycoprotein receptor
    Orexin receptor 2
    antigen identified by monoclonal antibody MRC OX-2 receptor
    cell surface glycoprotein OX2 receptor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021325.4 → NP_067300.1  cell surface glycoprotein CD200 receptor 1 precursor

      See identical proteins and their annotated locations for NP_067300.1

      Status: VALIDATED

      Source sequence(s)
      AC122217
      Consensus CDS
      CCDS28189.1
      UniProtKB/Swiss-Prot
      Q9ES57
      Related
      ENSMUSP00000053822.9, ENSMUST00000057488.15
      Conserved Domains (3) summary
      smart00410
      Location:106 → 146
      IG_like; Immunoglobulin like
      pfam07686
      Location:42 → 147
      V-set; Immunoglobulin V-set domain
      cl11960
      Location:162 → 222
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      44586141..44615341
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ES57.1 GenPept UniProtKB/Swiss-Prot:Q9ES57

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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