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    Adam24 ADAM metallopeptidase domain 24 [ Mus musculus (house mouse) ]

    Gene ID: 13526, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adam24provided by MGI
    Official Full Name
    ADAM metallopeptidase domain 24provided by MGI
    Primary source
    MGI:MGI:105984
    See related
    Ensembl:ENSMUSG00000046723 AllianceGenome:MGI:105984
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dtgn5
    Summary
    This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. This gene is expressed in a regulated fashion during spermatogenesis. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional metalloprotease enzyme. Male mice lacking the encoded protein exhibit reduced fertility due to the higher incidence of polyspermic embryos. This gene is located adjacent to other ADAM genes on chromosome 8. [provided by RefSeq, May 2016]
    Expression
    Restricted expression toward testis adult (RPKM 17.4) See more
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    Genomic context

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    See Adam24 in Genome Data Viewer
    Location:
    8 A4; 8 23.89 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (41128118..41135238)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (40675077..40682199)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene zinc finger, DHHC domain containing 2 Neighboring gene CCR4-NOT transcription complex, subunit 7 Neighboring gene vacuolar protein sorting 37A Neighboring gene myotubularin related protein 7 Neighboring gene STARR-seq mESC enhancer starr_21271 Neighboring gene STARR-seq mESC enhancer starr_21272 Neighboring gene STARR-seq mESC enhancer starr_21273 Neighboring gene high mobility group box 3 pseudogene Neighboring gene a disintegrin and metallopeptidase domain 39 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Testase 1 (ADAM 24) a plasma membrane-anchored sperm protease implicated in sperm function during epididymal maturation or fertilization. Zhu GZ, et al. J Cell Sci, 2001 May. PMID 11309208
    2. Testase 1 (ADAM 24) a sperm surface metalloprotease is required for normal fertility in mice. Zhu GZ, et al. Mol Reprod Dev, 2009 Nov. PMID 19670298
    3. Identification of four novel ADAMs with potential roles in spermatogenesis and fertilization. Zhu GZ, et al. Gene, 1999 Jul 8. PMID 10395895
    4. A family of cellular proteins related to snake venom disintegrins. Weskamp G, et al. Proc Natl Acad Sci U S A, 1994 Mar 29. PMID 8146185, Free PMC Article
    5. Comprehensive analysis of reproductive ADAMs: relationship of ADAM4 and ADAM6 with an ADAM complex required for fertilization in mice. Han C, et al. Biol Reprod, 2009 May. PMID 19129510

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables integrin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in male gonad development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within prevention of polyspermy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in sperm head plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm head plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 24
    Names
    a disintegrin and metallopeptidase domain 24 (testase 1)
    a disintegrin and metalloproteinase domain 24 (testase 1)
    disintegrin 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010086.5 → NP_034216.3  disintegrin and metalloproteinase domain-containing protein 24 preproprotein

      See identical proteins and their annotated locations for NP_034216.3

      Status: REVIEWED

      Source sequence(s)
      AK029528, AK133199, BB616396
      Consensus CDS
      CCDS22255.1
      UniProtKB/Swiss-Prot
      A6H683, E9QL68, Q9R160
      UniProtKB/TrEMBL
      Q8CDV3
      Related
      ENSMUSP00000050727.4, ENSMUST00000051614.5
      Conserved Domains (4) summary
      smart00608
      Location:492 → 628
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:209 → 395
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:415 → 488
      Disintegrin
      pfam01562
      Location:42 → 160
      Pep_M12B_propep; Reprolysin family propeptide

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      41128118..41135238
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509261.1 → XP_006509324.1  disintegrin and metalloproteinase domain-containing protein 24 isoform X1

      See identical proteins and their annotated locations for XP_006509324.1

      UniProtKB/Swiss-Prot
      A6H683, E9QL68, Q9R160
      UniProtKB/TrEMBL
      Q8CDV3
      Conserved Domains (4) summary
      smart00608
      Location:492 → 628
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:209 → 395
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:415 → 488
      Disintegrin
      pfam01562
      Location:42 → 160
      Pep_M12B_propep; Reprolysin family propeptide
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R160.2 GenPept UniProtKB/Swiss-Prot:Q9R160

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