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    Ubap1l ubiquitin-associated protein 1-like [ Mus musculus (house mouse) ]

    Gene ID: 208080, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ubap1lprovided by MGI
    Official Full Name
    ubiquitin-associated protein 1-likeprovided by MGI
    Primary source
    MGI:MGI:2685360
    See related
    Ensembl:ENSMUSG00000086228 AllianceGenome:MGI:2685360
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm514
    Summary
    Predicted to enable ubiquitin binding activity. Predicted to be involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Predicted to be part of ESCRT I complex. Orthologous to human UBAP1L (ubiquitin associated protein 1 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 4.4), CNS E18 (RPKM 2.0) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ubap1l in Genome Data Viewer
    Location:
    9 C; 9 35.26 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (65268311..65287659)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (65361029..65380377)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 19219 Neighboring gene STARR-seq mESC enhancer starr_24452 Neighboring gene programmed cell death 7 Neighboring gene predicted gene, 17875 Neighboring gene kelch repeat and BTB (POZ) domain containing 13 Neighboring gene RAS-like, family 12 Neighboring gene solute carrier family 51, beta subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    2. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of ESCRT I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-associated protein 1-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111145.2 → NP_001104615.1  ubiquitin-associated protein 1-like isoform 1

      See identical proteins and their annotated locations for NP_001104615.1

      Status: VALIDATED

      Source sequence(s)
      AC114645
      Consensus CDS
      CCDS52836.1
      UniProtKB/TrEMBL
      G3UW59
      Related
      ENSMUSP00000128815.2, ENSMUST00000147185.3
      Conserved Domains (1) summary
      cd14316
      Location:344 → 368
      UBA2_UBAP1_like; UBA2 domain found in ubiquitin-associated protein 1 (UBAP-1) and similar proteins

    2. NM_001373909.1 → NP_001360838.1  ubiquitin-associated protein 1-like isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC114645
      Conserved Domains (1) summary
      cd14316
      Location:344 → 380
      UBA2_UBAP1_like; UBA2 domain found in ubiquitin-associated protein 1 (UBAP-1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      65268311..65287659
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313256.2 → XP_017168745.1  ubiquitin-associated protein 1-like isoform X1

      UniProtKB/TrEMBL
      A0A6I8MWX1
      Conserved Domains (1) summary
      cd14316
      Location:209 → 245
      UBA2_UBAP1_like; UBA2 domain found in ubiquitin-associated protein 1 (UBAP-1) and similar proteins

    2. XM_017313257.3 → XP_017168746.1  ubiquitin-associated protein 1-like isoform X1

      UniProtKB/TrEMBL
      A0A6I8MWX1
      Related
      ENSMUSP00000159297.2, ENSMUST00000239433.2
      Conserved Domains (1) summary
      cd14316
      Location:209 → 245
      UBA2_UBAP1_like; UBA2 domain found in ubiquitin-associated protein 1 (UBAP-1) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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