Scara5 scavenger receptor class A, member 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Scara5provided by MGI
Official Full Name: scavenger receptor class A, member 5provided by MGI
Primary source: MGI:MGI:1918395
See related: Ensembl:ENSMUSG00000022032 AllianceGenome:MGI:1918395
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tesr; 4932433F15Rik; 4933425F03Rik
Summary: Enables ferritin receptor activity. Involved in several processes, including intracellular iron ion homeostasis; iron ion transmembrane transport; and protein homotrimerization. Acts upstream of or within cellular response to heat. Located in cell surface and plasma membrane. Is expressed in several structures, including eye; gonad; heart; spinal cord; and vertebral pre-cartilage condensation. Orthologous to human SCARA5 (scavenger receptor class A member 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in bladder adult (RPKM 37.1), mammary gland adult (RPKM 14.4) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D1; 14 34.35 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (65903852..66002275)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (65666403..65764826)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions of ferritin with scavenger receptor class A members.
Title: Interactions of ferritin with scavenger receptor class A members.
This study demonstrates that SCARA5 is a positive regulator in adipocyte lineage commitment and early adipogenesis in mesenchymal stem cells.
Title: SCARA5 plays a critical role in the commitment of mesenchymal stem cells to adipogenesis.
Scara5 was downregulated, pointing out this receptor as a potential player implicated in retinopathy and also as a possible therapeutic target.
Title: L-ferritin binding to scara5: a new iron traffic pathway potentially implicated in retinopathy.
Defects in fibroblast SCARA5 can underlie some forms of autoimmune disease.
Title: Progressive reactive lymphoid connective tissue disease and development of autoantibodies in scavenger receptor A5-deficient mice.
plasma membrane protein SCARA5 can contribute to human hepatocellular carcinoma (HCC) tumorigenesis and metastasis via activation of the FAK signaling pathway.
Title: Genetic and epigenetic silencing of SCARA5 may contribute to human hepatocellular carcinoma by activating FAK signaling.
Tesr is differentially expressed in the male vs. female embryonic and postnatal gonad, and may play a role in phagocytosis of apoptotic cells, cell-cell adhesion, and defense. [Tesr - testis expressed scavenger receptor]
Title: Novel scavenger receptor gene is differentially expressed in the embryonic and adult mouse testis.
Data show that the transferrin receptor TfR1 provided transferrin to the ureteric bud, but not to the capsule or the stroma, and that Scara5 bound serum ferritin and then stimulated its endocytosis from the cell surface with consequent iron delivery.
Title: Scara5 is a ferritin receptor mediating non-transferrin iron delivery.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Targeted (1) 1 citation

General gene information

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Markers

AV278087 (e-PCR)
- UniSTS:180686

UniSTS:478958 (e-PCR)
- UniSTS:478958

Scara5 (e-PCR), detects polymorphism
- UniSTS:478958

30.MMHAP14FRB12.seq (e-PCR)
- UniSTS:123892

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ferritin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to heat	IDA Inferred from Direct Assay more info	PubMed
involved_in endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular iron ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in iron ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in protein homotrimerization	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in endocytic vesicle membrane	TAS Traceable Author Statement more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: scavenger receptor class A member 5

Names: scavenger receptor class A, member 5 (putative); testis expressed scavenger receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001168318.1 → NP_001161790.1 scavenger receptor class A member 5 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks two 3' exons but has an alternate 3' exon, as compared to variant 1. The resulting isoform (2) is shorter and has a different C-terminus, as compared to isoform 1.

Source sequence(s)

AK016543, AK033154, BY791906

Consensus CDS

CCDS49523.1

UniProtKB/Swiss-Prot

Q8K299

Related

ENSMUSP00000063391.7, ENSMUST00000069226.7

Conserved Domains (2) summary

pfam01391
Location:306 → 373

Collagen; Collagen triple helix repeat (20 copies)

pfam08496
Location:67 → 115

Peptidase_S49_N; Peptidase family S49 N-terminal
NM_028903.2 → NP_083179.2 scavenger receptor class A member 5 isoform 1

See identical proteins and their annotated locations for NP_083179.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AK133176, BC016096

Consensus CDS

CCDS27214.1

UniProtKB/Swiss-Prot

Q8BZZ2, Q8K299, Q8R330, Q91WD6, Q9CUC3, Q9D4G8

Related

ENSMUSP00000022610.9, ENSMUST00000022610.15

Conserved Domains (3) summary

PRK09039
Location:55 → 249

PRK09039; peptidoglycan -binding protein

smart00202
Location:389 → 489

SR; Scavenger receptor Cys-rich

pfam01391
Location:318 → 373

Collagen; Collagen triple helix repeat (20 copies)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

65903852..66002275

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158851.1 → XP_036014744.1 scavenger receptor class A member 5 isoform X1

UniProtKB/Swiss-Prot

Q8BZZ2, Q8K299, Q8R330, Q91WD6, Q9CUC3, Q9D4G8

Conserved Domains (3) summary

PRK09039
Location:55 → 249

PRK09039; peptidoglycan -binding protein

smart00202
Location:389 → 489

SR; Scavenger receptor Cys-rich

pfam01391
Location:318 → 373

Collagen; Collagen triple helix repeat (20 copies)