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    Synrg synergin, gamma [ Mus musculus (house mouse) ]

    Gene ID: 217030, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Synrgprovided by MGI
    Official Full Name
    synergin, gammaprovided by MGI
    Primary source
    MGI:MGI:1354742
    See related
    Ensembl:ENSMUSG00000034940 AllianceGenome:MGI:1354742
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SYNG; Ap1gbp1
    Summary
    Predicted to be involved in endocytosis and protein transport. Predicted to be located in several cellular components, including Golgi apparatus; clathrin-coated vesicle; and perinuclear region of cytoplasm. Predicted to be part of clathrin coat of trans-Golgi network vesicle. Is expressed in several structures, including cardiovascular system; gallbladder; genitourinary system; gut; and nervous system. Orthologous to human SYNRG (synergin gamma). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 8.6), thymus adult (RPKM 8.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Synrg in Genome Data Viewer
    Location:
    11 C; 11 51.25 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (83855217..83935404)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (83964390..84044578)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_30206 Neighboring gene STARR-seq mESC enhancer starr_30207 Neighboring gene HNF1 homeobox B Neighboring gene predicted gene, 51869 Neighboring gene STARR-positive B cell enhancer ABC_E5256 Neighboring gene STARR-positive B cell enhancer ABC_E11769 Neighboring gene DExD box helicase 52 Neighboring gene STARR-positive B cell enhancer mm9_chr11:83845520-83845821 Neighboring gene STARR-seq mESC enhancer starr_30212 Neighboring gene dual specificity phosphatase 14 Neighboring gene transcriptional adaptor 2A Neighboring gene acetyl-Coenzyme A carboxylase alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and cloning of differentially expressed genes by long-distance differential display. Jurecic R, et al. Anal Biochem, 1998 Jun 1. PMID 9618202
    2. Binding partners for the COOH-terminal appendage domains of the GGAs and gamma-adaptin. Lui WW, et al. Mol Biol Cell, 2003 Jun. PMID 12808037, Free PMC Article
    3. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873
    4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • L71-5

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of clathrin coat of trans-Golgi network vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of clathrin coat of trans-Golgi network vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in clathrin-coated vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    synergin gamma
    Names
    AP1 gamma subunit binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001405109.1 → NP_001392038.1  synergin gamma isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL645615
      UniProtKB/Swiss-Prot
      Q5SV84, Q5SV85, Q6PHT6
      UniProtKB/TrEMBL
      V9GX40
      Related
      ENSMUSP00000138969.2, ENSMUST00000183456.8

    2. NM_001405112.1 → NP_001392041.1  synergin gamma isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL645615
      UniProtKB/Swiss-Prot
      Q5SV84, Q5SV85, Q6PHT6

    3. NM_001405113.1 → NP_001392042.1  synergin gamma isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL645615
      UniProtKB/Swiss-Prot
      Q5SV84, Q5SV85, Q6PHT6
      Related
      ENSMUSP00000059000.9, ENSMUST00000049714.15

    4. NM_001405115.1 → NP_001392044.1  synergin gamma isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL645615
      UniProtKB/Swiss-Prot
      Q5SV84, Q5SV85, Q6PHT6

    5. NM_001405116.1 → NP_001392045.1  synergin gamma isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL645615
      UniProtKB/Swiss-Prot
      Q5SV84, Q5SV85, Q6PHT6

    6. NM_001405118.1 → NP_001392047.1  synergin gamma isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL645615
      UniProtKB/Swiss-Prot
      Q5SV84, Q5SV85, Q6PHT6
      UniProtKB/TrEMBL
      V9GXD9
      Related
      ENSMUSP00000139103.2, ENSMUST00000183714.8

    7. NM_001405121.1 → NP_001392050.1  synergin gamma isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL645615

    8. NM_001405122.1 → NP_001392051.1  synergin gamma isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL645615

    9. NM_001405123.1 → NP_001392052.1  synergin gamma isoform 10

      Status: VALIDATED

      Source sequence(s)
      AL645615

    10. NM_194341.3 → NP_919322.1  synergin gamma isoform 7

      See identical proteins and their annotated locations for NP_919322.1

      Status: VALIDATED

      Source sequence(s)
      AL645615
      Consensus CDS
      CCDS25181.1
      UniProtKB/Swiss-Prot
      Q5SV84, Q5SV85, Q6PHT6
      Related
      ENSMUSP00000090510.6, ENSMUST00000092834.12
      Conserved Domains (2) summary
      cd00052
      Location:235 → 286
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      cl00928
      Location:113 → 147
      dsDNA_bind; Double-stranded DNA-binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      83855217..83935404
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532979.5 → XP_006533042.1  synergin gamma isoform X1

      UniProtKB/Swiss-Prot
      Q5SV84, Q5SV85, Q6PHT6
      Conserved Domains (4) summary
      cd00052
      Location:415 → 466
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam09606
      Location:30 → 242
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam15346
      Location:114 → 147
      ARGLU; Arginine and glutamate-rich 1
      pfam16014
      Location:469 → 537
      SAP130_C; Histone deacetylase complex subunit SAP130 C-terminus

    2. XM_006532985.5 → XP_006533048.1  synergin gamma isoform X8

      UniProtKB/Swiss-Prot
      Q5SV84, Q5SV85, Q6PHT6
      Conserved Domains (4) summary
      cd00052
      Location:236 → 287
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam09606
      Location:30 → 129
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam15346
      Location:114 → 147
      ARGLU; Arginine and glutamate-rich 1
      pfam16014
      Location:290 → 358
      SAP130_C; Histone deacetylase complex subunit SAP130 C-terminus

    3. XM_006532988.5 → XP_006533051.1  synergin gamma isoform X10

      UniProtKB/Swiss-Prot
      Q5SV84, Q5SV85, Q6PHT6
      Conserved Domains (4) summary
      cd00052
      Location:236 → 287
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam09606
      Location:30 → 129
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam15346
      Location:114 → 147
      ARGLU; Arginine and glutamate-rich 1
      pfam16014
      Location:290 → 358
      SAP130_C; Histone deacetylase complex subunit SAP130 C-terminus

    4. XM_006532986.4 → XP_006533049.1  synergin gamma isoform X9

      UniProtKB/Swiss-Prot
      Q5SV84, Q5SV85, Q6PHT6
      Conserved Domains (3) summary
      cd00052
      Location:235 → 286
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam09606
      Location:30 → 333
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam15346
      Location:113 → 146
      ARGLU; Arginine and glutamate-rich 1

    5. XM_006532981.3 → XP_006533044.1  synergin gamma isoform X4

      UniProtKB/Swiss-Prot
      Q5SV84, Q5SV85, Q6PHT6
      Conserved Domains (4) summary
      cd00052
      Location:399 → 450
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam09606
      Location:14 → 226
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam15346
      Location:98 → 131
      ARGLU; Arginine and glutamate-rich 1
      pfam16014
      Location:453 → 521
      SAP130_C; Histone deacetylase complex subunit SAP130 C-terminus

    6. XM_006532982.3 → XP_006533045.1  synergin gamma isoform X5

      UniProtKB/Swiss-Prot
      Q5SV84, Q5SV85, Q6PHT6
      Conserved Domains (4) summary
      cd00052
      Location:398 → 449
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam09606
      Location:14 → 225
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam15346
      Location:97 → 130
      ARGLU; Arginine and glutamate-rich 1
      pfam16014
      Location:452 → 520
      SAP130_C; Histone deacetylase complex subunit SAP130 C-terminus

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001115009.1: Suppressed sequence

      Description
      NM_001115009.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5SV85.1 GenPept UniProtKB/Swiss-Prot:Q5SV85

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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