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    Cdh18 cadherin 18 [ Mus musculus (house mouse) ]

    Gene ID: 320865, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cdh18provided by MGI
    Official Full Name
    cadherin 18provided by MGI
    Primary source
    MGI:MGI:1344366
    See related
    Ensembl:ENSMUSG00000040420 AllianceGenome:MGI:1344366
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cdh14l; B230220E17Rik; Tg(GFAP-APOE_i4)1Hol
    Summary
    Predicted to enable beta-catenin binding activity and cadherin binding activity. Predicted to be involved in several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell-cell adhesion mediated by cadherin; and cell-cell junction organization. Predicted to be part of catenin complex. Predicted to be active in adherens junction. Is expressed in several structures, including central nervous system; eye; and testis. Orthologous to human CDH18 (cadherin 18). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 8.0), cortex adult (RPKM 2.6) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cdh18 in Genome Data Viewer
    Location:
    15 A2; 15 8.54 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (22548984..23477577)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (22548898..23477491)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene cadherin 12 Neighboring gene STARR-seq mESC enhancer starr_38121 Neighboring gene STARR-seq mESC enhancer starr_38122 Neighboring gene STARR-seq mESC enhancer starr_38123 Neighboring gene STARR-seq mESC enhancer starr_38124 Neighboring gene predicted gene, 25101 Neighboring gene STARR-seq mESC enhancer starr_38125 Neighboring gene STARR-seq mESC enhancer starr_38126 Neighboring gene STARR-seq mESC enhancer starr_38127 Neighboring gene STARR-seq mESC enhancer starr_38128 Neighboring gene STARR-seq mESC enhancer starr_38129 Neighboring gene STARR-seq mESC enhancer starr_38132 Neighboring gene STARR-seq mESC enhancer starr_38133 Neighboring gene STARR-seq mESC enhancer starr_38134 Neighboring gene STARR-seq mESC enhancer starr_38135 Neighboring gene predicted gene, 41278 Neighboring gene heterogeneous nuclear ribonucleoprotein A1-like 2, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_38138 Neighboring gene STARR-seq mESC enhancer starr_38139 Neighboring gene STARR-seq mESC enhancer starr_38140 Neighboring gene STARR-seq mESC enhancer starr_38141 Neighboring gene STARR-seq mESC enhancer starr_38142 Neighboring gene STARR-seq mESC enhancer starr_38144 Neighboring gene STARR-seq mESC enhancer starr_38145 Neighboring gene predicted gene, 19840 Neighboring gene STARR-seq mESC enhancer starr_38147 Neighboring gene STARR-seq mESC enhancer starr_38148 Neighboring gene predicted gene, 24656 Neighboring gene STARR-seq mESC enhancer starr_38149 Neighboring gene predicted gene 6533 Neighboring gene predicted gene, 23980

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Role of Impaired Receptor Trafficking in Mediating the Pathological Effects of APOE4 in Alzheimer's Disease. Safieh M, et al. J Alzheimers Dis, 2024. PMID 38217595, Free PMC Article
    2. Apolipoprotein E 4 triggers multiple pathway-mediated Ca2+ overload, causes CaMK II phosphorylation abnormity and aggravates oxidative stress caused cerebral cortical neuron damage. Xu D, et al. Eur Rev Med Pharmacol Sci, 2017 Dec. PMID 29272008
    3. Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins. Sun Y, et al. J Neurosci, 1998 May 1. PMID 9547235, Free PMC Article
    4. Multiple cadherin mRNA expression and developmental regulation of a novel cadherin in the developing mouse eye. Faulkner-Jones BE, et al. Exp Neurol, 1999 Apr. PMID 10328938
    5. Expression of human apolipoprotein E downregulates amyloid precursor protein-induced ischemic susceptibility. Koistinaho M, et al. Stroke, 2002 Jul. PMID 12105373

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Role of Impaired Receptor Trafficking in Mediating the Pathological Effects of APOE4 in Alzheimer's Disease.
      Title: The Role of Impaired Receptor Trafficking in Mediating the Pathological Effects of APOE4 in Alzheimer's Disease.
    2. The Rhox gene cluster suppresses germline LINE1 transposition.
      Title: The Rhox gene cluster suppresses germline LINE1 transposition.
    3. APOE triggers Ca2+ overload through NMDAR and CaMK II signaling pathway, both of which cause Ca2+ concentration increasing, CaMK II phosphorylation abnormity, and finally aggravate oxidative stress damaged neurons apoptosis
      Title: Apolipoprotein E 4 triggers multiple pathway-mediated Ca2+ overload, causes CaMK II phosphorylation abnormity and aggravates oxidative stress caused cerebral cortical neuron damage.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Transgenic (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables beta-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cadherin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in adherens junction organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion mediated by cadherin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell junction assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catenin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cadherin-18
    Names
    GFAP-apoE4 line1
    Tg(GFAP-APOE*4)1Hol
    Tg(GFAP-APOE4)1Hol

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081299.1 → NP_001074768.1  cadherin-18 precursor

      See identical proteins and their annotated locations for NP_001074768.1

      Status: VALIDATED

      Source sequence(s)
      AC121357, AC134595, AC134864, AC157478
      Consensus CDS
      CCDS49585.1
      UniProtKB/TrEMBL
      E9Q9Q6
      Related
      ENSMUSP00000130851.2, ENSMUST00000164787.8
      Conserved Domains (3) summary
      cd11304
      Location:387 → 484
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:79 → 157
      CA; Cadherin repeats
      pfam01049
      Location:637 → 783
      Cadherin_C; Cadherin cytoplasmic region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      22548984..23477577
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520095.4 → XP_006520158.1  cadherin-18 isoform X1

      See identical proteins and their annotated locations for XP_006520158.1

      UniProtKB/TrEMBL
      E9Q9Q6
      Conserved Domains (3) summary
      cd11304
      Location:387 → 484
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:79 → 157
      CA; Cadherin repeats
      pfam01049
      Location:637 → 783
      Cadherin_C; Cadherin cytoplasmic region

    2. XM_006520096.5 → XP_006520159.1  cadherin-18 isoform X1

      See identical proteins and their annotated locations for XP_006520159.1

      UniProtKB/TrEMBL
      E9Q9Q6
      Conserved Domains (3) summary
      cd11304
      Location:387 → 484
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:79 → 157
      CA; Cadherin repeats
      pfam01049
      Location:637 → 783
      Cadherin_C; Cadherin cytoplasmic region

    3. XM_011245360.4 → XP_011243662.1  cadherin-18 isoform X1

      See identical proteins and their annotated locations for XP_011243662.1

      UniProtKB/TrEMBL
      E9Q9Q6
      Conserved Domains (3) summary
      cd11304
      Location:387 → 484
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:79 → 157
      CA; Cadherin repeats
      pfam01049
      Location:637 → 783
      Cadherin_C; Cadherin cytoplasmic region

    4. XM_006520094.5 → XP_006520157.1  cadherin-18 isoform X1

      See identical proteins and their annotated locations for XP_006520157.1

      UniProtKB/TrEMBL
      E9Q9Q6
      Conserved Domains (3) summary
      cd11304
      Location:387 → 484
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:79 → 157
      CA; Cadherin repeats
      pfam01049
      Location:637 → 783
      Cadherin_C; Cadherin cytoplasmic region

    5. XM_036159468.1 → XP_036015361.1  cadherin-18 isoform X1

      UniProtKB/TrEMBL
      E9Q9Q6
      Conserved Domains (3) summary
      cd11304
      Location:387 → 484
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:79 → 157
      CA; Cadherin repeats
      pfam01049
      Location:637 → 783
      Cadherin_C; Cadherin cytoplasmic region

    6. XM_030248609.2 → XP_030104469.1  cadherin-18 isoform X3

      UniProtKB/TrEMBL
      E9Q941
      Related
      ENSMUSP00000128643.2, ENSMUST00000165614.9
      Conserved Domains (2) summary
      cd11304
      Location:387 → 484
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:79 → 157
      CA; Cadherin repeats

    7. XM_030248608.2 → XP_030104468.1  cadherin-18 isoform X2

      UniProtKB/TrEMBL
      A0A2I3BPS8
      Related
      ENSMUSP00000153905.2, ENSMUST00000226693.2
      Conserved Domains (2) summary
      cd11304
      Location:387 → 484
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:79 → 157
      CA; Cadherin repeats

    8. XM_030248607.2 → XP_030104467.1  cadherin-18 isoform X1

      UniProtKB/TrEMBL
      E9Q9Q6
      Conserved Domains (3) summary
      cd11304
      Location:387 → 484
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:79 → 157
      CA; Cadherin repeats
      pfam01049
      Location:637 → 783
      Cadherin_C; Cadherin cytoplasmic region
    Nucleotide Protein Strain
    Heading Accession and Version

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