Becn2 beclin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Becn2provided by MGI
Official Full Name: beclin 2provided by MGI
Primary source: MGI:MGI:2684950
See related: Ensembl:ENSMUSG00000104158 AllianceGenome:MGI:2684950
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm104; Gm38100; Beclin-2
Summary: Predicted to enable phosphatidylinositol 3-kinase binding activity and protein-macromolecule adaptor activity. Involved in G protein-coupled receptor catabolic process; autophagy; and endosome to lysosome transport. Acts upstream of or within glucose homeostasis. Predicted to be located in cytoplasm. Predicted to be part of phosphatidylinositol 3-kinase complex, class III, type I and phosphatidylinositol 3-kinase complex, class III, type II. Predicted to be active in phagophore assembly site. Is expressed in several structures, including liver; reproductive system; skeletal muscle; stomach; and thymus. Orthologous to human BECN2 (beclin 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 1; 1 H4

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (175747895..175749791)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (175920329..175922225)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sesamin-mediated high expression of BECN2 ameliorates cartilage endplate degeneration by reducing autophagy and inflammation.
Title: Sesamin-mediated high expression of BECN2 ameliorates cartilage endplate degeneration by reducing autophagy and inflammation.
Deciphering functional roles and interplay between Beclin1 and Beclin2 in autophagosome formation and mitophagy.
Title: Deciphering functional roles and interplay between Beclin1 and Beclin2 in autophagosome formation and mitophagy.
Beclin 2 negatively regulates innate immune signaling and tumor development.
Title: Beclin 2 negatively regulates innate immune signaling and tumor development.
a protein involved in macroautophagy/autophagy (a conserved lysosomal degradation pathway), BECN2 (beclin 2), mediates cannabinoid tolerance by preventing CNR1 recycling and resensitization after prolonged agonist exposure, and deletion of Becn2 rescues CNR1 activity in mouse brain and conveys resistance to analgesic tolerance to chronic cannabinoids
Title: Autophagy activation by novel inducers prevents BECN2-mediated drug tolerance to cannabinoids.
Monoallelic loss of Becn2 accelerates progression of vGPCR-induced lesions resembling human Kaposi's sarcoma. Beclin 2 is protects against the pathogenic effects of KSHV GPCR by facilitating its endolysosomal degradation.
Title: Endolysosomal trafficking of viral G protein-coupled receptor functions in innate immunity and control of viral oncogenesis.
Study identified a previously uncharacterized mammalian-specific protein, Beclin 2, which, like Beclin 1, functions in autophagy and interacts with class III PI3K complex components.[Beclin 2]
Title: Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phosphatidylinositol 3-kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables protein-macromolecule adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in G protein-coupled receptor catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within G protein-coupled receptor catabolic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in G protein-coupled receptor catabolic process	ISO Inferred from Sequence Orthology more info
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within autophagy	ISO Inferred from Sequence Orthology more info	PubMed
involved_in autophagy	ISO Inferred from Sequence Orthology more info
involved_in cellular response to nitrogen starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in endosome to lysosome transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endosome to lysosome transport	ISO Inferred from Sequence Orthology more info	PubMed
involved_in endosome to lysosome transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucose homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in late endosome to vacuole transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitophagy	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in phagophore assembly site	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphatidylinositol 3-kinase complex, class III, type I	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphatidylinositol 3-kinase complex, class III, type II	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: beclin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290692.1 → NP_001277621.1 beclin-2

See identical proteins and their annotated locations for NP_001277621.1

Status: VALIDATED

Source sequence(s)

BB838749, CJ207428, KF511582

Consensus CDS

CCDS78757.1

UniProtKB/Swiss-Prot

P0DM65, S5WDD2

UniProtKB/TrEMBL

A0A0J9YUN7

Related

ENSMUSP00000143887.2, ENSMUST00000201297.2

Conserved Domains (2) summary

pfam04111
Location:126 → 440

APG6; Autophagy protein Apg6

pfam12925
Location:151 → 220

APP_E2; E2 domain of amyloid precursor protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

175747895..175749791

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NG_028451.1: Suppressed sequence

Description

NG_028451.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.