Ptx3 pentraxin related gene [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptx3provided by MGI
Official Full Name: pentraxin related geneprovided by MGI
Primary source: MGI:MGI:104641
See related: Ensembl:ENSMUSG00000027832 AllianceGenome:MGI:104641
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TSG-14
Summary: Enables (1->3)-beta-D-glucan binding activity. Acts upstream of or within several processes, including opsonization; ovarian cumulus expansion; and positive regulation of nitric oxide biosynthetic process. Located in extracellular matrix. Is expressed in dentate gyrus subgranular zone and inner ear. Human ortholog(s) of this gene implicated in cystic fibrosis and invasive aspergillosis. Orthologous to human PTX3 (pentraxin 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in limb E14.5 (RPKM 16.3), CNS E11.5 (RPKM 14.4) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 E1; 3 30.25 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (66127308..66133227)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (66219887..66225806)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NAT10 promotes synovial aggression by increasing the stability and translation of N4-acetylated PTX3 mRNA in rheumatoid arthritis.
Title: NAT10 promotes synovial aggression by increasing the stability and translation of N4-acetylated PTX3 mRNA in rheumatoid arthritis.
PTX3 promotes cementum formation and cementoblast differentiation via HA/ITGB1/FAK/YAP1 signaling pathway.
Title: PTX3 promotes cementum formation and cementoblast differentiation via HA/ITGB1/FAK/YAP1 signaling pathway.
PTX3 mediates PI3K/AKT/mTOR signaling to downregulate apoptosis and autophagy to attenuate myocardial injury in sepsis.
Title: PTX3 mediates PI3K/AKT/mTOR signaling to downregulate apoptosis and autophagy to attenuate myocardial injury in sepsis.
Pentraxin 3 exacerbates psoriasiform dermatitis through regulation of macrophage polarization.
Title: Pentraxin 3 exacerbates psoriasiform dermatitis through regulation of macrophage polarization.
Inactivation of pentraxin 3 suppresses M2-like macrophage activity and immunosuppression in colon cancer.
Title: Inactivation of pentraxin 3 suppresses M2-like macrophage activity and immunosuppression in colon cancer.
Genetic Deficiency of the Long Pentraxin 3 Affects Osteogenesis and Osteoclastogenesis in Homeostatic and Inflammatory Conditions.
Title: Genetic Deficiency of the Long Pentraxin 3 Affects Osteogenesis and Osteoclastogenesis in Homeostatic and Inflammatory Conditions.
PTX3 shapes profibrotic immune cells and epithelial/fibroblast repair and regeneration in a murine model of pulmonary fibrosis.
Title: PTX3 shapes profibrotic immune cells and epithelial/fibroblast repair and regeneration in a murine model of pulmonary fibrosis.
Thioredoxin A of Streptococcus suis Serotype 2 Contributes to Virulence by Inhibiting the Expression of Pentraxin 3 to Promote Survival Within Macrophages.
Title: Thioredoxin A of Streptococcus suis Serotype 2 Contributes to Virulence by Inhibiting the Expression of Pentraxin 3 to Promote Survival Within Macrophages.
Regulation of inflammation and protection against invasive pneumococcal infection by the long pentraxin PTX3.
Title: Regulation of inflammation and protection against invasive pneumococcal infection by the long pentraxin PTX3.
[Advances on pentraxin 3 in osteoporosis and fracture healing].
Title: [Advances on pentraxin 3 in osteoporosis and fracture healing].

Submit: New GeneRIF Correction See all GeneRIFs (94)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC304098P4 (e-PCR)
- UniSTS:272523

AI607804 (e-PCR)
- UniSTS:178842

U33842 (e-PCR)
- UniSTS:178844

Ptx3 (e-PCR), detects polymorphism
- UniSTS:144305

X83601 (e-PCR)
- UniSTS:125873

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables (1->3)-beta-D-glucan binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables complement component C1q complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables complement component C1q complex binding	IEA Inferred from Electronic Annotation more info
enables complement component C1q complex binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables virion binding	IEA Inferred from Electronic Annotation more info
enables virion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within extracellular matrix organization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within extracellular matrix organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation by host of viral exo-alpha-sialidase activity	IEA Inferred from Electronic Annotation more info
involved_in negative regulation by host of viral exo-alpha-sialidase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation by host of viral glycoprotein metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation by host of viral glycoprotein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation by host of viral process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of exo-alpha-sialidase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glycoprotein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral entry into host cell	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of viral entry into host cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within opsonization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ovarian cumulus expansion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within ovarian cumulus expansion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of nitric oxide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to yeast	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: pentraxin-related protein PTX3

Names: pentaxin related; pentaxin-related protein PTX3; pentraxin 3; tumor necrosis factor-inducible gene 14 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.