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    Proser2 proline and serine rich 2 [ Mus musculus (house mouse) ]

    Gene ID: 227545, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Proser2provided by MGI
    Official Full Name
    proline and serine rich 2provided by MGI
    Primary source
    MGI:MGI:2442238
    See related
    Ensembl:ENSMUSG00000045319 AllianceGenome:MGI:2442238
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5430407P10Rik
    Summary
    Is expressed in several structures, including alimentary system; cranial ganglion; cranium; sensory organ; and submandibular gland primordium. Orthologous to human PROSER2 (proline and serine rich 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in stomach adult (RPKM 13.4), liver adult (RPKM 5.9) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Proser2 in Genome Data Viewer
    Location:
    2 A1; 2 3.62 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (6103304..6135100, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (6098493..6130291, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03581 Neighboring gene UPF2 regulator of nonsense transcripts homolog (yeast) Neighboring gene STARR-seq mESC enhancer starr_03584 Neighboring gene STARR-seq mESC enhancer starr_03586 Neighboring gene predicted gene, 30136 Neighboring gene TRAF-interacting protein pseudogene Neighboring gene predicted gene 10857 Neighboring gene STARR-seq mESC enhancer starr_03588 Neighboring gene RIKEN cDNA A230108P19 gene Neighboring gene enoyl Coenzyme A hydratase domain containing 3 Neighboring gene predicted gene, 54100

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Understanding the development of oral epithelial organs through single cell transcriptomic analysis. Ye Q, et al. Development, 2022 Aug 15. PMID 35831953, Free PMC Article
    2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC36947

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    proline and serine-rich protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159657.2 → NP_001153129.1  proline and serine-rich protein 2

      See identical proteins and their annotated locations for NP_001153129.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
      Source sequence(s)
      AL928735
      Consensus CDS
      CCDS15671.1
      UniProtKB/Swiss-Prot
      Q3V1L9, Q8C5R2, Q8R017, Q8R2Z9
      Related
      ENSMUSP00000060780.6, ENSMUST00000054254.12
      Conserved Domains (2) summary
      PHA03247
      Location:97 → 261
      PHA03247; large tegument protein UL36; Provisional
      pfam15385
      Location:439 → 469
      SARG; Specifically androgen-regulated gene protein

    2. NM_144883.5 → NP_659132.2  proline and serine-rich protein 2

      See identical proteins and their annotated locations for NP_659132.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
      Source sequence(s)
      AL928735
      Consensus CDS
      CCDS15671.1
      UniProtKB/Swiss-Prot
      Q3V1L9, Q8C5R2, Q8R017, Q8R2Z9
      Related
      ENSMUSP00000110592.3, ENSMUST00000114942.9
      Conserved Domains (2) summary
      PHA03247
      Location:97 → 261
      PHA03247; large tegument protein UL36; Provisional
      pfam15385
      Location:439 → 469
      SARG; Specifically androgen-regulated gene protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      6103304..6135100 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011238976.4 → XP_011237278.1  proline and serine-rich protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011237278.1

      UniProtKB/Swiss-Prot
      Q3V1L9, Q8C5R2, Q8R017, Q8R2Z9
      Conserved Domains (2) summary
      PHA03247
      Location:97 → 261
      PHA03247; large tegument protein UL36; Provisional
      pfam15385
      Location:439 → 469
      SARG; Specifically androgen-regulated gene protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C5R2.3 GenPept UniProtKB/Swiss-Prot:Q8C5R2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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