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    Nudt5 nudix hydrolase 5 [ Mus musculus (house mouse) ]

    Gene ID: 53893, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nudt5provided by MGI
    Official Full Name
    nudix hydrolase 5provided by MGI
    Primary source
    MGI:MGI:1858232
    See related
    Ensembl:ENSMUSG00000025817 AllianceGenome:MGI:1858232
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables nucleoside diphosphate phosphatase activity and snoRNA binding activity. Acts upstream of or within nucleobase-containing compound metabolic process. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; musculoskeletal system; nervous system; and respiratory system. Orthologous to human NUDT5 (nudix hydrolase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 10.2), liver E14 (RPKM 9.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nudt5 in Genome Data Viewer
    Location:
    2 A1; 2 3.62 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (5849839..5875631)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (5845034..5870820)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr2:5661717-5662018 Neighboring gene predicted gene, 29857 Neighboring gene STARR-seq mESC enhancer starr_03574 Neighboring gene STARR-seq mESC enhancer starr_03576 Neighboring gene cell division cycle 123 Neighboring gene predicted gene, 29984 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:5766095-5766344 Neighboring gene STARR-seq mESC enhancer starr_03579 Neighboring gene predicted gene 13199 Neighboring gene SEC61 translocon subunit alpha 2 Neighboring gene STARR-positive B cell enhancer mm9_chr2:5816293-5816594 Neighboring gene predicted gene 13267 Neighboring gene dehydrogenase E1 and transketolase domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a new member of the Nudix hydrolases from human and mouse. Yang H, et al. J Biol Chem, 2000 Mar 24. PMID 10722730
    2. Multiple mRNA decapping enzymes in mammalian cells. Song MG, et al. Mol Cell, 2010 Nov 12. PMID 21070968, Free PMC Article
    3. Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry. Schweppe DK, et al. Proc Natl Acad Sci U S A, 2017 Feb 14. PMID 28130547, Free PMC Article
    4. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article
    5. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 8-oxo-GDP phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 8-oxo-dGDP phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 8-oxo-dGDP phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ADP-ribose diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ADP-ribose diphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ADP-ribose diphosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ADP-sugar diphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ADP-sugar diphosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nucleoside diphosphate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleotidyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotidyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables snoRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ATP generation from poly-ADP-D-ribose IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ATP generation from poly-ADP-D-ribose ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in D-ribose catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in D-ribose catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within nucleobase-containing compound metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nucleoside phosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribonucleoside diphosphate catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribonucleoside diphosphate catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ribose phosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ADP-sugar pyrophosphatase
    Names
    8-oxo-dGDP phosphatase
    nuclear ATP-synthesis protein NUDIX5
    nucleoside diphosphate-linked moiety X motif 5
    nudix (nucleoside diphosphate linked moiety X)-type motif 5
    nudix motif 5
    NP_001405336.1
    NP_001405337.1
    NP_001405338.1
    NP_001405339.1
    NP_001405340.1
    NP_001405341.1
    NP_001405342.1
    NP_001405343.1
    NP_001405344.1
    NP_001405345.1
    NP_001405346.1
    NP_058614.1
    XP_006497574.1
    XP_036018286.1
    XP_036018287.1
    XP_036018288.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418407.1 → NP_001405336.1  ADP-sugar pyrophosphatase isoform b

      Status: VALIDATED

      Source sequence(s)
      AL928924

    2. NM_001418408.1 → NP_001405337.1  ADP-sugar pyrophosphatase isoform b

      Status: VALIDATED

      Source sequence(s)
      AL928924

    3. NM_001418409.1 → NP_001405338.1  ADP-sugar pyrophosphatase isoform c

      Status: VALIDATED

      Source sequence(s)
      AL928924
      UniProtKB/TrEMBL
      A2ATT5

    4. NM_001418410.1 → NP_001405339.1  ADP-sugar pyrophosphatase isoform c

      Status: VALIDATED

      Source sequence(s)
      AL928924
      UniProtKB/TrEMBL
      A2ATT5

    5. NM_001418411.1 → NP_001405340.1  ADP-sugar pyrophosphatase isoform c

      Status: VALIDATED

      Source sequence(s)
      AL928924
      UniProtKB/TrEMBL
      A2ATT5

    6. NM_001418412.1 → NP_001405341.1  ADP-sugar pyrophosphatase isoform c

      Status: VALIDATED

      Source sequence(s)
      AL928924
      UniProtKB/TrEMBL
      A2ATT5

    7. NM_001418413.1 → NP_001405342.1  ADP-sugar pyrophosphatase isoform c

      Status: VALIDATED

      Source sequence(s)
      AL928924
      UniProtKB/TrEMBL
      A2ATT5
      Related
      ENSMUSP00000117670.2, ENSMUST00000127116.7

    8. NM_001418414.1 → NP_001405343.1  ADP-sugar pyrophosphatase isoform c

      Status: VALIDATED

      Source sequence(s)
      AL928924
      UniProtKB/TrEMBL
      A2ATT5

    9. NM_001418415.1 → NP_001405344.1  ADP-sugar pyrophosphatase isoform d

      Status: VALIDATED

      Source sequence(s)
      AL928924

    10. NM_001418416.1 → NP_001405345.1  ADP-sugar pyrophosphatase isoform d

      Status: VALIDATED

      Source sequence(s)
      AL928924

    11. NM_001418417.1 → NP_001405346.1  ADP-sugar pyrophosphatase isoform d

      Status: VALIDATED

      Source sequence(s)
      AL928924

    12. NM_016918.4 → NP_058614.1  ADP-sugar pyrophosphatase isoform a

      See identical proteins and their annotated locations for NP_058614.1

      Status: VALIDATED

      Source sequence(s)
      AL928924
      Consensus CDS
      CCDS15667.1
      UniProtKB/Swiss-Prot
      A2ATT6, Q99KM4, Q9JKX6
      Related
      ENSMUSP00000026927.4, ENSMUST00000026927.10
      Conserved Domains (1) summary
      cd03424
      Location:59 → 206
      ADPRase_NUDT5; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+, ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      5849839..5875631
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162394.1 → XP_036018287.1  ADP-sugar pyrophosphatase isoform X3

      UniProtKB/Swiss-Prot
      A2ATT6, Q99KM4, Q9JKX6
      Conserved Domains (1) summary
      cd03424
      Location:59 → 206
      ADPRase_NUDT5; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+, ...

    2. XM_036162395.1 → XP_036018288.1  ADP-sugar pyrophosphatase isoform X3

      UniProtKB/Swiss-Prot
      A2ATT6, Q99KM4, Q9JKX6
      Conserved Domains (1) summary
      cd03424
      Location:59 → 206
      ADPRase_NUDT5; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+, ...

    3. XM_006497511.4 → XP_006497574.1  ADP-sugar pyrophosphatase isoform X2

      Conserved Domains (1) summary
      cd03424
      Location:105 → 249
      ADPRase_NUDT5; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+, ...

    4. XM_036162393.1 → XP_036018286.1  ADP-sugar pyrophosphatase isoform X1

      Conserved Domains (1) summary
      cd03424
      Location:105 → 252
      ADPRase_NUDT5; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+, ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JKX6.1 GenPept UniProtKB/Swiss-Prot:Q9JKX6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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