Slc7a2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc7a2provided by MGI
Official Full Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 2provided by MGI
Primary source: MGI:MGI:99828
See related: Ensembl:ENSMUSG00000031596 AllianceGenome:MGI:99828
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tea; 20.5; Cat2; Atrc2; CAT-2
Summary: Enables L-arginine transmembrane transporter activity. Involved in L-arginine transmembrane transport and regulation of macrophage activation. Acts upstream of or within several processes, including macrophage activation; nitric oxide biosynthetic process; and nitric oxide production involved in inflammatory response. Located in membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and respiratory system. Orthologous to human SLC7A2 (solute carrier family 7 member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in liver adult (RPKM 24.2), liver E18 (RPKM 9.0) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A4; 8 23.89 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (41315404..41375107)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (40862341..40922070)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Elevated SLC7A2 expression is associated with an abnormal neuroinflammatory response and nitrosative stress in Huntington's disease.
Title: Elevated SLC7A2 expression is associated with an abnormal neuroinflammatory response and nitrosative stress in Huntington's disease.
Integrated Amino Acids and Transcriptome Analysis Reveals Arginine Transporter SLC7A2 Is a Novel Regulator of Myogenic Differentiation.
Title: Integrated Amino Acids and Transcriptome Analysis Reveals Arginine Transporter SLC7A2 Is a Novel Regulator of Myogenic Differentiation.
SLC3A2 and SLC7A2 Mediate the Exogenous Putrescine-Induced Adipocyte Differentiation.
Title: SLC3A2 and SLC7A2 Mediate the Exogenous Putrescine-Induced Adipocyte Differentiation.
Molecular Determinants for Nitric Oxide Regulation of the Murine Cationic Amino Acid Transporter CAT-2A.
Title: Molecular Determinants for Nitric Oxide Regulation of the Murine Cationic Amino Acid Transporter CAT-2A.
Characterisation of genes differentially expressed in macrophages by virulent and attenuated Mycobacterium tuberculosis through RNA-Seq analysis.
Title: Characterisation of genes differentially expressed in macrophages by virulent and attenuated Mycobacterium tuberculosis through RNA-Seq analysis.
In wild-type mice exposed to hyperoxia, the exhaled nitric oxide (exNO) was twofold greater than in wild-type mice exposed to normoxia ( P < 0.005), whereas in slc7a2(-/-) mice there was no significant difference between exNO in animals exposed to hyperoxia or normoxia ( P = 0.95). These results are consistent with our hypothesis that lack of CAT-2 protects mice from acute lung injury.
Title: Deficiency of cationic amino acid transporter-2 protects mice from hyperoxia-induced lung injury.
data reveal that SLC7A2 has a significant role in the protection from colitis-associated carcinogenesis (CAC) in the setting of chronic colitis, and suggest that the decreased SLC7A2 in inflammatory bowel disease (IBD) may contribute to CAC risk.
Title: Loss of solute carrier family 7 member 2 exacerbates inflammation-associated colon tumorigenesis.
A time-dependent decrease in serum and tissue ADMA and increase in mRNA expression of DDAH-1 and PRMT-1 as well as higher rates of mRNA expression of CAT-1 and lower rates of CAT-2A and CAT-2B were found after 8-week MCD diet.
Title: MCD diet-induced steatohepatitis is associated with alterations in asymmetric dimethylarginine (ADMA) and its transporters.
In the absence of CAT2, Myeloid-derived suppressor cells display diminished capacity for controlling T cell immunity in prostate inflammation and cancer models, where the loss of CAT2 results in enhanced antitumor activity.
Title: Expression of Cationic Amino Acid Transporter 2 Is Required for Myeloid-Derived Suppressor Cell-Mediated Control of T Cell Immunity.
demonstration of how most nuclear-retained CTN-RNAs stabilize at the periphery of paraspeckles, how CTN-RNA regulates its protein-coding partner, and how the mCAT2 gene can maintain a stable expression
Title: Dynamical analysis of mCAT2 gene models with CTN-RNA nuclear retention.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI158848 (e-PCR)
- UniSTS:159756

Slc7a2 (e-PCR), detects polymorphism
- UniSTS:547359

AU048745 (e-PCR)
- UniSTS:145195

Slc7a2 (e-PCR), detects polymorphism
- UniSTS:527022

L29006 (e-PCR)
- UniSTS:124893

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-arginine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-arginine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-arginine transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables L-arginine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-lysine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-ornithine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in L-alpha-amino acid transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in L-amino acid transport	ISO Inferred from Sequence Orthology more info
involved_in L-arginine import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-arginine import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-arginine transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within L-arginine transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in L-arginine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in L-ornithine transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in amino acid import across plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within macrophage activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nitric oxide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nitric oxide production involved in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of macrophage activation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cationic amino acid transporter 2

Names: T-cell early activation protein; amino acid transporter, cationic 2 (low affinity); cationic amino acid transporter 2A; cationic amino acid transporter 2B; low affinity cationic amino acid transporter 2; solute carrier family 7 member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044740.2 → NP_001038205.1 cationic amino acid transporter 2 isoform 2

See identical proteins and their annotated locations for NP_001038205.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate exon in the coding region compared to variant 1. The resulting protein (isoform 2) is longer but has the same N- and C-termini compared to isoform 1.

Source sequence(s)

AC116511

Consensus CDS

CCDS40327.1

UniProtKB/TrEMBL

E9QJY0

Related

ENSMUSP00000096414.4, ENSMUST00000098816.10

Conserved Domains (1) summary

TIGR00906
Location:5 → 608

2A0303; cationic amino acid transport permease
NM_007514.3 → NP_031540.2 cationic amino acid transporter 2 isoform 1

See identical proteins and their annotated locations for NP_031540.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the shorter protein (isoform 1).

Source sequence(s)

AC116511, AI158848, BB648063, L11600

Consensus CDS

CCDS22258.1

UniProtKB/Swiss-Prot

E9QPL9, P18581, Q38RA6, Q3TB99, Q3U3R5

UniProtKB/TrEMBL

E9QJY0

Related

ENSMUSP00000058866.9, ENSMUST00000057784.15

Conserved Domains (1) summary

TIGR00906
Location:5 → 607

2A0303; cationic amino acid transport permease

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

41315404..41375107

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006509253.5 → XP_006509316.1 cationic amino acid transporter 2 isoform X4

See identical proteins and their annotated locations for XP_006509316.1

UniProtKB/TrEMBL

E9QJY0

Conserved Domains (1) summary

TIGR00906
Location:5 → 608

2A0303; cationic amino acid transport permease
XM_006509252.4 → XP_006509315.1 cationic amino acid transporter 2 isoform X3

UniProtKB/TrEMBL

E9QJY0

Conserved Domains (1) summary

TIGR00906
Location:26 → 629

2A0303; cationic amino acid transport permease
XM_006509250.5 → XP_006509313.1 cationic amino acid transporter 2 isoform X1

UniProtKB/TrEMBL

E9QJY0

Conserved Domains (1) summary

TIGR00906
Location:67 → 670

2A0303; cationic amino acid transport permease
XM_006509251.5 → XP_006509314.2 cationic amino acid transporter 2 isoform X2

UniProtKB/Swiss-Prot

E9QPL9, P18581, Q38RA6, Q3TB99, Q3U3R5

UniProtKB/TrEMBL

E9QJY0

Related

ENSMUSP00000112848.2, ENSMUST00000118432.2

Conserved Domains (1) summary

TIGR00906
Location:5 → 607

2A0303; cationic amino acid transport permease