U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ints2 integrator complex subunit 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360589, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Ints2provided by RGD
    Official Full Name
    integrator complex subunit 2provided by RGD
    Primary source
    RGD:1305547
    See related
    EnsemblRapid:ENSRNOG00000059997 AllianceGenome:RGD:1305547
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305547
    Summary
    Predicted to be involved in snRNA 3'-end processing. Predicted to be located in cytoplasm and nucleus. Predicted to be part of integrator complex. Orthologous to human INTS2 (integrator complex subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 70.5), Adrenal (RPKM 62.0) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Ints2 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (71529021..71576529, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (71031647..71079138, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (73632805..73690952, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein eL21-like Neighboring gene T-box transcription factor 4 Neighboring gene transfer RNA valine (anticodon AAC) 22 Neighboring gene BRCA1 interacting DNA helicase 1 Neighboring gene mediator complex subunit 13 Neighboring gene uncharacterized LOC120095332

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the integrator complex. Jodoin JN, et al. Mol Biol Cell, 2013 Sep. PMID 23904267, Free PMC Article
    2. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. Baillat D, et al. Cell, 2005 Oct 21. PMID 16239144
    3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of integrator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of integrator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    integrator complex subunit 2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100630.2 → NP_001094100.2  integrator complex subunit 2

      See identical proteins and their annotated locations for NP_001094100.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HHQ4
      Related
      ENSRNOP00000101742.1, ENSRNOT00000163492.1
      Conserved Domains (1) summary
      pfam14750
      Location:24 → 1127
      INTS2; Integrator complex subunit 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      71529021..71576529 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008768072.4 → XP_008766294.1  integrator complex subunit 2 isoform X1

      UniProtKB/TrEMBL
      A0A096MJ28
      Related
      ENSRNOP00000067968.2, ENSRNOT00000075843.4
      Conserved Domains (1) summary
      pfam14750
      Location:24 → 1128
      INTS2; Integrator complex subunit 2

    2. XM_063269393.1 → XP_063125463.1  integrator complex subunit 2 isoform X2

    RNA

    1. XR_005489890.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous