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    Dmap1 DNA methyltransferase 1-associated protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298447, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dmap1provided by RGD
    Official Full Name
    DNA methyltransferase 1-associated protein 1provided by RGD
    Primary source
    RGD:1311295
    See related
    EnsemblRapid:ENSRNOG00000019407 AllianceGenome:RGD:1311295
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity and transcription corepressor activity. Involved in response to ethanol. Predicted to be located in cytosol; nucleoplasm; and replication fork. Predicted to be part of NuA4 histone acetyltransferase complex; Swr1 complex; and nucleosome. Orthologous to human DMAP1 (DNA methyltransferase 1 associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 101.3), Thymus (RPKM 97.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dmap1 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (136380211..136388229, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (131143726..131151760, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (136533791..136541795, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486975 Neighboring gene ERI1 exoribonuclease family member 3 Neighboring gene iron-sulfur cluster assembly 1 homolog, mitochondrial-like Neighboring gene uncharacterized LOC134486976 Neighboring gene uncharacterized LOC102553953

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Effects of topiramate on ethanol-cocaine interactions and DNA methyltransferase gene expression in the rat prefrontal cortex. Echeverry-Alzate V, et al. Br J Pharmacol, 2014 Jun. PMID 24527678, Free PMC Article
    2. Subcellular localization of RPB5-mediating protein and its putative functional partner. Delgermaa L, et al. Mol Cell Biol, 2004 Oct. PMID 15367675, Free PMC Article
    3. DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. Rountree MR, et al. Nat Genet, 2000 Jul. PMID 10888872
    4. The INO80 family of chromatin-remodeling enzymes: regulators of histone variant dynamics. Watanabe S, et al. Cold Spring Harb Symp Quant Biol, 2010. PMID 21502417
    5. Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. Doyon Y, et al. Mol Cell Biol, 2004 Mar. PMID 14966270, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC109435

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to ethanol IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NuA4 histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Swr1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nucleosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in replication fork ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA methyltransferase 1-associated protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001015006.1 → NP_001015006.1  DNA methyltransferase 1-associated protein 1

      See identical proteins and their annotated locations for NP_001015006.1

      Status: PROVISIONAL

      Source sequence(s)
      BC092651
      UniProtKB/TrEMBL
      A0A8I6A1B5, F7FQE3, Q568Y6
      Related
      ENSRNOP00000026336.4, ENSRNOT00000026336.7
      Conserved Domains (2) summary
      pfam05499
      Location:243 → 402
      DMAP1; DNA methyltransferase 1-associated protein 1 (DMAP1)
      pfam16282
      Location:124 → 203
      SANT_DAMP1_like; SANT/Myb-like domain of DAMP1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      136380211..136388229 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109606.2 → XP_038965534.1  DNA methyltransferase 1-associated protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A1B5, F7FQE3, Q568Y6
      Conserved Domains (2) summary
      pfam05499
      Location:243 → 402
      DMAP1; DNA methyltransferase 1-associated protein 1 (DMAP1)
      pfam16282
      Location:124 → 203
      SANT_DAMP1_like; SANT/Myb-like domain of DAMP1
    Nucleotide Protein Strain
    Heading Accession and Version

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