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    Psmf1 proteasome inhibitor subunit 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 689852, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Psmf1provided by RGD
    Official Full Name
    proteasome inhibitor subunit 1provided by RGD
    Primary source
    RGD:1587528
    See related
    EnsemblRapid:ENSRNOG00000009640 AllianceGenome:RGD:1587528
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable proteasome binding activity; protein heterodimerization activity; and protein homodimerization activity. Predicted to be involved in negative regulation of proteasomal protein catabolic process and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol; endoplasmic reticulum; and perinuclear region of cytoplasm. Predicted to be part of proteasome complex. Orthologous to human PSMF1 (proteasome inhibitor subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 319.0), Spleen (RPKM 181.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Psmf1 in Genome Data Viewer
    Location:
    3q41
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (160695744..160720915, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (140235371..140260546, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (147238111..147263275, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene transmembrane 74B, opposite strand Neighboring gene transmembrane protein 74B Neighboring gene uncharacterized LOC134486185 Neighboring gene heterogeneous nuclear ribonucleoprotein H1, pseudogene 2 Neighboring gene R-spondin 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. cDNA cloning, expression, and functional characterization of PI31, a proline-rich inhibitor of the proteasome. McCutchen-Maloney SL, et al. J Biol Chem, 2000 Jun 16. PMID 10764772
    2. Structure of a conserved dimerization domain within the F-box protein Fbxo7 and the PI31 proteasome inhibitor. Kirk R, et al. J Biol Chem, 2008 Aug 8. PMID 18495667
    3. Isolation of mammalian 26S proteasomes and p97/VCP complexes using the ubiquitin-like domain from HHR23B reveals novel proteasome-associated proteins. Besche HC, et al. Biochemistry, 2009 Mar 24. PMID 19182904, Free PMC Article
    4. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC93913

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proteasome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proteasome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables proteasome binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of proteasomal protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of proteasomal protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    proteasome inhibitor PI31 subunit
    Names
    proteasome (prosome, macropain) inhibitor subunit 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001101005.1 → NP_001094475.1  proteasome inhibitor PI31 subunit

      See identical proteins and their annotated locations for NP_001094475.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083575
      UniProtKB/Swiss-Prot
      Q5XIU5
      UniProtKB/TrEMBL
      A6KHK5, F1M7S2
      Related
      ENSRNOP00000038926.6, ENSRNOT00000029620.7
      Conserved Domains (2) summary
      pfam08577
      Location:186 → 248
      PI31_Prot_C; PI31 proteasome regulator
      pfam11566
      Location:11 → 148
      PI31_Prot_N; PI31 proteasome regulator N-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      160695744..160720915 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105878.2 → XP_038961806.1  proteasome inhibitor PI31 subunit isoform X1

      UniProtKB/TrEMBL
      F1M7S2
      Conserved Domains (2) summary
      pfam08577
      Location:156 → 218
      PI31_Prot_C; PI31 proteasome regulator
      pfam11566
      Location:10 → 118
      PI31_Prot_N; PI31 proteasome regulator N-terminal

    2. XM_063284578.1 → XP_063140648.1  proteasome inhibitor PI31 subunit isoform X2

      UniProtKB/TrEMBL
      A6KHK6
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XIU5.1 GenPept UniProtKB/Swiss-Prot:Q5XIU5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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