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    Babam1 BRISC and BRCA1 A complex member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290631, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Babam1provided by RGD
    Official Full Name
    BRISC and BRCA1 A complex member 1provided by RGD
    Primary source
    RGD:1359516
    See related
    EnsemblRapid:ENSRNOG00000017071 AllianceGenome:RGD:1359516
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Merit40
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including DNA repair-dependent chromatin remodeling; mitotic G2 DNA damage checkpoint signaling; and positive regulation of DNA repair. Predicted to act upstream of or within hematopoietic stem cell proliferation. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of BRCA1-A complex and BRISC complex. Predicted to be active in nuclear body. Orthologous to human BABAM1 (BRISC and BRCA1 A complex member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 127.8), Thymus (RPKM 123.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Babam1 in Genome Data Viewer
    Location:
    16p14
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (18102885..18108916)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (18068830..18074938)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (19792720..19798886)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene nuclear receptor subfamily 2, group F, member 6 Neighboring gene USH1 protein network component harmonin binding protein 1 Neighboring gene uncharacterized LOC134482465 Neighboring gene ankyrin repeat and LEM domain containing 1 Neighboring gene RB binding protein 7, chromatin remodeling factor, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MERIT40 deficiency expands hematopoietic stem cell pools by regulating thrombopoietin receptor signaling. Rozenova K, et al. Blood, 2015 Mar 12. PMID 25636339, Free PMC Article
    2. MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks. Shao G, et al. Genes Dev, 2009 Mar 15. PMID 19261746, Free PMC Article
    3. K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1. Cooper EM, et al. EMBO J, 2009 Mar 18. PMID 19214193, Free PMC Article
    4. MERIT40 facilitates BRCA1 localization and DNA damage repair. Feng L, et al. Genes Dev, 2009 Mar 15. PMID 19261748, Free PMC Article
    5. NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control. Wang B, et al. Genes Dev, 2009 Mar 15. PMID 19261749, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94542

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair-dependent chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA repair-dependent chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within hematopoietic stem cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic G2 DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic G2 DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic G2 DNA damage checkpoint signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to ionizing radiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of BRCA1-A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of BRCA1-A complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of BRCA1-A complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of BRISC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of BRISC complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of BRISC complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nuclear body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    BRISC and BRCA1-A complex member 1
    Names
    BRCA1-A complex subunit MERIT40
    mediator of RAP80 interactions and targeting subunit of 40 kDa
    new component of the BRCA1-A complex

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006964.1 → NP_001006965.1  BRISC and BRCA1-A complex member 1

      See identical proteins and their annotated locations for NP_001006965.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083685
      UniProtKB/Swiss-Prot
      Q5XIJ6
      UniProtKB/TrEMBL
      A6K9T3
      Related
      ENSRNOP00000022938.3, ENSRNOT00000022938.7
      Conserved Domains (2) summary
      PRK07003
      Location:24 → 93
      PRK07003; DNA polymerase III subunit gamma/tau
      cd21502
      Location:96 → 316
      vWA_BABAM1; Von-Willebrand factor A (vWA) domain found in BRISC and BRCA1-A complex member 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      18102885..18108916
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094296.2 → XP_038950224.1  BRISC and BRCA1-A complex member 1 isoform X1

      UniProtKB/TrEMBL
      A6K9T2
      Conserved Domains (1) summary
      cd21502
      Location:96 → 196
      vWA_BABAM1; Von-Willebrand factor A (vWA) domain found in BRISC and BRCA1-A complex member 1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XIJ6.1 GenPept UniProtKB/Swiss-Prot:Q5XIJ6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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