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    Osbpl7 oxysterol binding protein-like 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303497, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Osbpl7provided by RGD
    Official Full Name
    oxysterol binding protein-like 7provided by RGD
    Primary source
    RGD:1309141
    See related
    EnsemblRapid:ENSRNOG00000009473 AllianceGenome:RGD:1309141
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cholesterol binding activity. Predicted to be involved in cellular response to cholesterol and positive regulation of proteasomal protein catabolic process. Predicted to be located in autophagosome and nucleoplasm. Predicted to be active in several cellular components, including cytosol; nuclear membrane; and perinuclear endoplasmic reticulum. Orthologous to human OSBPL7 (oxysterol binding protein like 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 59.1), Spleen (RPKM 49.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Osbpl7 in Genome Data Viewer
    Location:
    10q31
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (82532335..82549999)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (82035995..82053566)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (84986330..85003947)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene secernin 2 Neighboring gene leucine rich repeat containing 46 Neighboring gene mitochondrial ribosomal protein L10 Neighboring gene T-box transcription factor 21 Neighboring gene TBK1 binding protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression of oxysterol binding protein isoforms in opisthorchiasis-associated cholangiocarcinoma: a potential molecular marker for tumor metastasis. Loilome W, et al. Parasitol Int, 2012 Mar. PMID 21763455
    2. OSBP-related protein 7 interacts with GATE-16 and negatively regulates GS28 protein stability. Zhong W, et al. Exp Cell Res, 2011 Oct 1. PMID 21669198
    3. Subfamily III of mammalian oxysterol-binding protein (OSBP) homologues: the expression and intracellular localization of ORP3, ORP6, and ORP7. Lehto M, et al. Cell Tissue Res, 2004 Jan. PMID 14593528
    4. The mammalian oxysterol-binding protein-related proteins (ORPs) bind 25-hydroxycholesterol in an evolutionarily conserved pocket. Suchanek M, et al. Biochem J, 2007 Aug 1. PMID 17428193, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cholesterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cholesterol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to cholesterol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in autophagosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nuclear membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in perinuclear endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    oxysterol-binding protein-related protein 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107044.1 → NP_001100514.1  oxysterol-binding protein-related protein 7

      See identical proteins and their annotated locations for NP_001100514.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A6HIJ1, D4A0G0
      Related
      ENSRNOP00000061773.1, ENSRNOT00000067665.3
      Conserved Domains (2) summary
      cd13287
      Location:27 → 131
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:455 → 796
      Oxysterol_BP; Oxysterol-binding protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      82532335..82549999
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247299.5 → XP_006247361.1  oxysterol-binding protein-related protein 7 isoform X1

      See identical proteins and their annotated locations for XP_006247361.1

      UniProtKB/TrEMBL
      A0A0G2K0D5
      Related
      ENSRNOP00000102945.1, ENSRNOT00000136209.1
      Conserved Domains (3) summary
      cd13287
      Location:27 → 149
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam00169
      Location:51 → 139
      PH; PH domain
      pfam01237
      Location:473 → 814
      Oxysterol_BP; Oxysterol-binding protein

    2. XM_006247300.5 → XP_006247362.1  oxysterol-binding protein-related protein 7 isoform X1

      See identical proteins and their annotated locations for XP_006247362.1

      UniProtKB/TrEMBL
      A0A0G2K0D5
      Conserved Domains (3) summary
      cd13287
      Location:27 → 149
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam00169
      Location:51 → 139
      PH; PH domain
      pfam01237
      Location:473 → 814
      Oxysterol_BP; Oxysterol-binding protein

    RNA

    1. XR_357857.5 RNA Sequence

    2. XR_005489854.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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