Fzd5 frizzled class receptor 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fzd5provided by RGD
Official Full Name: frizzled class receptor 5provided by RGD
Primary source: RGD:631406
See related: EnsemblRapid:ENSRNOG00000014678 AllianceGenome:RGD:631406
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables Wnt-protein binding activity. Involved in presynapse assembly. Is active in glutamatergic synapse. Orthologous to human FZD5 (frizzled class receptor 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: 9q32

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (73606860..73614039, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (66113096..66120276, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (71443784..71445541, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MicroRNA-216b was overexposed in diabetic myocardial microvascular endothelial cells and its downregulation may actively enhance angiogenesis in diabetic angiopathy through inverse regulation on FZD5.
Title: MicroRNA-216b actively modulates diabetic angiopathy through inverse regulation on FZD5.
Fzd5 has a role in the establishment of neuronal polarity, and in the morphogenesis of neuronal processes
Title: Frizzled-5 receptor is involved in neuronal polarity and morphogenesis of hippocampal neurons.
WNT7A can specifically act via a Frizzled-5.LRP6 receptor complex in PC12 cells and that this activity can be antagonized by
Title: Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins.

Submit: New GeneRIF Correction

General gene information

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Markers

Fzd5 (e-PCR), detects polymorphism
- UniSTS:506911

Fzd5 (e-PCR), detects polymorphism
- UniSTS:516478

Fzd5 (e-PCR), detects polymorphism
- UniSTS:508390

Fzd5 (e-PCR), detects polymorphism
- UniSTS:547566

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables Wnt receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables Wnt receptor activity	IEA Inferred from Electronic Annotation more info
enables Wnt receptor activity	ISO Inferred from Sequence Orthology more info
enables Wnt receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables Wnt-protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables Wnt-protein binding	IEA Inferred from Electronic Annotation more info
enables Wnt-protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables Wnt-protein binding	ISO Inferred from Sequence Orthology more info
enables amyloid-beta binding	IEA Inferred from Electronic Annotation more info
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Spemann organizer formation	IEA Inferred from Electronic Annotation more info
involved_in Spemann organizer formation	ISO Inferred from Sequence Orthology more info
involved_in T cell differentiation in thymus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within T cell differentiation in thymus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in anterior/posterior axis specification, embryo	IEA Inferred from Electronic Annotation more info
involved_in anterior/posterior axis specification, embryo	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process involved in morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within apoptotic process involved in morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in branching involved in labyrinthine layer morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within branching involved in labyrinthine layer morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in canonical Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to molecule of bacterial origin	IEA Inferred from Electronic Annotation more info
involved_in cellular response to molecule of bacterial origin	ISO Inferred from Sequence Orthology more info
involved_in chorionic trophoblast cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chorionic trophoblast cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in embryonic axis specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic camera-type eye development	ISO Inferred from Sequence Orthology more info
involved_in embryonic camera-type eye morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in embryonic camera-type eye morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in eye development	ISO Inferred from Sequence Orthology more info
involved_in eye development	ISS Inferred from Sequence or Structural Similarity more info
involved_in glandular epithelial cell maturation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glandular epithelial cell maturation	ISO Inferred from Sequence Orthology more info
involved_in intestinal epithelial cell maturation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intestinal epithelial cell maturation	ISO Inferred from Sequence Orthology more info
involved_in labyrinthine layer blood vessel development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within labyrinthine layer blood vessel development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in non-canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in non-canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in non-canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in non-canonical Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of JUN kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell cytokine production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T cell cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 beta production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein targeting to mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in post-embryonic camera-type eye development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within post-embryonic camera-type eye development	ISO Inferred from Sequence Orthology more info
involved_in post-embryonic camera-type eye development	ISO Inferred from Sequence Orthology more info
involved_in presynapse assembly	EXP Inferred from Experiment more info	PubMed
involved_in presynapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in presynapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of bicellular tight junction assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of bicellular tight junction assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of chorionic trophoblast cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of chorionic trophoblast cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitophagy	ISO Inferred from Sequence Orthology more info	PubMed
involved_in syncytiotrophoblast cell differentiation involved in labyrinthine layer development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within syncytiotrophoblast cell differentiation involved in labyrinthine layer development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vasculature development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in axon	IEA Inferred from Electronic Annotation more info
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: frizzled-5

Names: frizzled family receptor 5; fz-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.