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    Fbxo44 F-box protein 44 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500587, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fbxo44provided by RGD
    Official Full Name
    F-box protein 44provided by RGD
    Primary source
    RGD:1562463
    See related
    EnsemblRapid:ENSRNOG00000009298 AllianceGenome:RGD:1562463
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562463
    Summary
    Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in ERAD pathway; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; and glycoprotein catabolic process. Predicted to act upstream of or within proteasomal protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human FBXO44 (F-box protein 44). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 270.2), Adrenal (RPKM 154.7) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fbxo44 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (163866517..163875928, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (158583363..158592510, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (164962921..164972273, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene mitotic arrest deficient 2 like 2 Neighboring gene F-box protein 6 Neighboring gene F-box protein 2 Neighboring gene uncharacterized LOC108351059

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases. Glenn KA, et al. J Biol Chem, 2008 May 9. PMID 18203720, Free PMC Article
    2. FBXO44-Mediated Degradation of RGS2 Protein Uniquely Depends on a Cullin 4B/DDB1 Complex. Sjögren B, et al. PLoS One, 2015. PMID 25970626, Free PMC Article
    3. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. Ebstein F, et al. Int J Biochem Cell Biol, 2009 May. PMID 19028597
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycoprotein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    F-box only protein 44

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191576.1 → NP_001178505.1  F-box only protein 44

      See identical proteins and their annotated locations for NP_001178505.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      D4A6R1
      Conserved Domains (2) summary
      pfam04300
      Location:72 → 250
      FBA; F-box associated region
      pfam12937
      Location:6 → 51
      F-box-like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      163866517..163875928 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063288302.1 → XP_063144372.1  F-box only protein 44 isoform X6

      UniProtKB/TrEMBL
      A0A8I6A0Z6

    2. XM_006239398.5 → XP_006239460.2  F-box only protein 44 isoform X5

      Conserved Domains (2) summary
      pfam04300
      Location:86 → 136
      FBA; F-box associated region
      pfam12937
      Location:20 → 67
      F-box-like; F-box-like

    3. XM_063288301.1 → XP_063144371.1  F-box only protein 44 isoform X3

      UniProtKB/TrEMBL
      D4A6R1

    4. XM_063288303.1 → XP_063144373.1  F-box only protein 44 isoform X6

      UniProtKB/TrEMBL
      A0A8I6A0Z6
      Related
      ENSRNOP00000084845.1, ENSRNOT00000101645.2

    5. XM_006239395.5 → XP_006239457.1  F-box only protein 44 isoform X4

      See identical proteins and their annotated locations for XP_006239457.1

      UniProtKB/TrEMBL
      D4A6R1
      Conserved Domains (2) summary
      pfam04300
      Location:72 → 250
      FBA; F-box associated region
      pfam12937
      Location:6 → 51
      F-box-like

    6. XM_006239393.3 → XP_006239455.1  F-box only protein 44 isoform X2

      Conserved Domains (2) summary
      pfam04300
      Location:162 → 212
      FBA; F-box associated region
      pfam12937
      Location:96 → 143
      F-box-like; F-box-like

    7. XM_006239392.3 → XP_006239454.1  F-box only protein 44 isoform X1

      Related
      ENSRNOP00000059513.4, ENSRNOT00000067059.5
      Conserved Domains (2) summary
      pfam04300
      Location:162 → 340
      FBA; F-box associated region
      pfam12937
      Location:96 → 143
      F-box-like; F-box-like

    8. XM_063288304.1 → XP_063144374.1  F-box only protein 44 isoform X8

    9. XM_039110645.2 → XP_038966573.1  F-box only protein 44 isoform X7

      UniProtKB/TrEMBL
      A6IU61
      Conserved Domains (2) summary
      pfam04300
      Location:162 → 182
      FBA; F-box associated region
      pfam12937
      Location:96 → 141
      F-box-like

    RNA

    1. XR_005504529.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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