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    Pir pirin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363465, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pirprovided by RGD
    Official Full Name
    pirinprovided by RGD
    Primary source
    RGD:1359212
    See related
    EnsemblRapid:ENSRNOG00000003674 AllianceGenome:RGD:1359212
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable metal ion binding activity; quercetin 2,3-dioxygenase activity; and transcription coregulator activity. Predicted to be involved in monocyte differentiation. Predicted to act upstream of or within myeloid cell differentiation. Predicted to be located in cytosol and nuclear body. Predicted to be active in nucleus. Orthologous to human PIR (pirin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 61.5), Adrenal (RPKM 57.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pir in Genome Data Viewer
    Location:
    Xq14
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (33740428..33851049, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (30108536..30219269, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (31852322..31968152, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class A Neighboring gene vascular endothelial growth factor D Neighboring gene ubiquitin-conjugating enzyme E2 K pseudogene Neighboring gene small nucleolar RNA SNORA17 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene U6 spliceosomal RNA Neighboring gene BMX non-receptor tyrosine kinase Neighboring gene cytochrome c oxidase assembly factor 5, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A small-molecule inhibitor shows that pirin regulates migration of melanoma cells. Miyazaki I, et al. Nat Chem Biol, 2010 Sep. PMID 20711196
    2. Pirin delocalization in melanoma progression identified by high content immuno-detection based approaches. Licciulli S, et al. BMC Cell Biol, 2010 Jan 20. PMID 20089166, Free PMC Article
    3. Pirin downregulation is a feature of AML and leads to impairment of terminal myeloid differentiation. Licciulli S, et al. Leukemia, 2010 Feb. PMID 20010624
    4. Identification of key genes and pathways associated with cholangiocarcinoma development based on weighted gene correlation network analysis. Liu J, et al. PeerJ, 2019. PMID 31687280, Free PMC Article
    5. Pirin is an iron-dependent redox regulator of NF-κB. Liu F, et al. Proc Natl Acad Sci U S A, 2013 Jun 11. PMID 23716661, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109484

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables quercetin 2,3-dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables quercetin 2,3-dioxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables quercetin 2,3-dioxygenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transcription coregulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coregulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in monocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within monocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within myeloid cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    pirin
    Names
    pirin (iron-binding nuclear protein)
    probable quercetin 2,3-dioxygenase PIR
    probable quercetinase
    NP_001009474.1
    XP_038955818.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009474.1 → NP_001009474.1  pirin

      See identical proteins and their annotated locations for NP_001009474.1

      Status: PROVISIONAL

      Source sequence(s)
      BC088290
      UniProtKB/Swiss-Prot
      Q5M827
      UniProtKB/TrEMBL
      A0A8I5ZXG1
      Related
      ENSRNOP00000004884.5, ENSRNOT00000004884.7
      Conserved Domains (3) summary
      COG1741
      Location:17 → 275
      YhaK; Redox-sensitive bicupin YhaK, pirin superfamily [General function prediction only]
      pfam02678
      Location:21 → 118
      Pirin; Pirin
      pfam05726
      Location:171 → 277
      Pirin_C; Pirin C-terminal cupin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      33740428..33851049 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099890.2 → XP_038955818.1  pirin isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZXG1
      Related
      ENSRNOP00000099013.1, ENSRNOT00000122305.1
      Conserved Domains (1) summary
      COG1741
      Location:31 → 272
      YhaK; Redox-sensitive bicupin YhaK, pirin superfamily [General function prediction only]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5M827.1 GenPept UniProtKB/Swiss-Prot:Q5M827

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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