Fam3a FAM3 metabolism regulating signaling molecule A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fam3aprovided by RGD
Official Full Name: FAM3 metabolism regulating signaling molecule Aprovided by RGD
Primary source: RGD:1562076
See related: EnsemblRapid:ENSRNOG00000060623 AllianceGenome:RGD:1562076
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1562076
Summary: Predicted to enable carbohydrate binding activity. Predicted to be involved in antimicrobial humoral immune response mediated by antimicrobial peptide and negative regulation of antifungal innate immune response. Predicted to be located in membrane. Predicted to be active in extracellular space. Orthologous to human FAM3A (FAM3 metabolism regulating signaling molecule A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 76.0), Adrenal (RPKM 56.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq37

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (157317993..157326640, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (152166716..152175327, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (156319687..156328974)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FAM3A Ameliorates Brain Impairment Induced by Hypoxia-Ischemia in Neonatal Rat.
Title: FAM3A Ameliorates Brain Impairment Induced by Hypoxia-Ischemia in Neonatal Rat.
NFE2/miR432-5p is reduced and FAM3a is increased with exercise in a rat model of insulin sensitivity
Title: Exercise induced improvements in insulin sensitivity are concurrent with reduced NFE2/miR-432-5p and increased FAM3A.
FAM3A not only inhibited ER Ca2+ release via inhibition of the surface expression of mGluR1/5, but also attenuated SOCE-mediated Ca2+ influx by disrupting the STIM1-Orai1 complex.
Title: FAM3A Protects Against Glutamate-Induced Toxicity by Preserving Calcium Homeostasis in Differentiated PC12 Cells.
FAM3A promotes proliferation and migration of vascular smooth muscle cells via P2Y1 receptor-mediated activation of Akt and ERK1/2 pathways.
Title: FAM3A promotes vascular smooth muscle cell proliferation and migration and exacerbates neointima formation in rat artery after balloon injury.

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General gene information

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Markers

RH129745 (e-PCR)
- UniSTS:213038

AI454555 (e-PCR)
- UniSTS:239525

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of antifungal innate immune response	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein FAM3A

Names: family with sequence similarity 3, member A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.