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    Dhrs7b dehydrogenase/reductase 7B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287380, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dhrs7bprovided by RGD
    Official Full Name
    dehydrogenase/reductase 7Bprovided by RGD
    Primary source
    RGD:1311243
    See related
    EnsemblRapid:ENSRNOG00000005360 AllianceGenome:RGD:1311243
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311243
    Summary
    Predicted to enable DNA-binding transcription factor binding activity and transcription corepressor activity. Predicted to be involved in ether lipid biosynthetic process and neutrophil differentiation. Predicted to act upstream of or within several processes, including brown fat cell differentiation; phosphatidylcholine biosynthetic process; and regulation of cold-induced thermogenesis. Predicted to be located in nucleus and peroxisome. Predicted to be part of transcription regulator complex. Predicted to be active in membrane. Orthologous to human DHRS7B (dehydrogenase/reductase 7B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 95.0), Thymus (RPKM 81.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dhrs7b in Genome Data Viewer
    Location:
    10q22
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (46003845..46036498)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (45504344..45537094)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (47065755..47111089)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene serine hydroxymethyltransferase 1 Neighboring gene basic transcription factor 3, pseudogene 15 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene transmembrane protein 11 Neighboring gene uncharacterized LOC102546946 Neighboring gene N-acetyltransferase domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Comparison of predicted and experimental subcellular localization of two putative rat steroid dehydrogenases from the short-chain dehydrogenase/reductase protein superfamily. Keller B, et al. Mol Cell Endocrinol, 2009 Mar 25. PMID 18775470
    2. Rat liver peroxisomes after fibrate treatment. A survey using quantitative mass spectrometry. Islinger M, et al. J Biol Chem, 2007 Aug 10. PMID 17522052
    3. Peroxisomal lipid synthesis regulates inflammation by sustaining neutrophil membrane phospholipid composition and viability. Lodhi IJ, et al. Cell Metab, 2015 Jan 6. PMID 25565205, Free PMC Article
    4. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
    5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The localization studies on rat short-chain dehydrogenases/reductases dhrs7b and dhrs8, are shown.
      Title: Comparison of predicted and experimental subcellular localization of two putative rat steroid dehydrogenases from the short-chain dehydrogenase/reductase protein superfamily.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105547

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in adipose tissue development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within adipose tissue development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in brown fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within brown fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ether lipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ether lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neutrophil differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neutrophil differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylcholine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphatidylcholine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cold-induced thermogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dehydrogenase/reductase SDR family member 7B
    Names
    SDR family dehydrogenase/reductase member 7B
    dehydrogenase/reductase (SDR family) member 7B
    short-chain dehydrogenase/reductase family 32C member 1
    NP_001008507.1
    XP_006246534.1
    XP_006246535.1
    XP_038941333.1
    XP_038941334.1
    XP_038941335.1
    XP_038941337.1
    XP_063124693.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008507.1 → NP_001008507.1  dehydrogenase/reductase SDR family member 7B

      See identical proteins and their annotated locations for NP_001008507.1

      Status: PROVISIONAL

      Source sequence(s)
      BC086453
      UniProtKB/Swiss-Prot
      A4GWE3, Q5RJY4
      UniProtKB/TrEMBL
      A0A8L2R5J7, A6HF59
      Related
      ENSRNOP00000063744.4, ENSRNOT00000065294.4
      Conserved Domains (2) summary
      cd05332
      Location:50 → 311
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
      PRK06181
      Location:52 → 321
      PRK06181; short chain dehydrogenase; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      46003845..46036498
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085407.2 → XP_038941335.1  dehydrogenase/reductase SDR family member 7B isoform X2

      UniProtKB/TrEMBL
      A6HF60
      Conserved Domains (1) summary
      cd05332
      Location:50 → 257
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

    2. XM_039085409.2 → XP_038941337.1  dehydrogenase/reductase SDR family member 7B isoform X3

      UniProtKB/TrEMBL
      A0A8L2R5J7
      Conserved Domains (1) summary
      cl21454
      Location:50 → 280
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    3. XM_039085405.2 → XP_038941333.1  dehydrogenase/reductase SDR family member 7B isoform X1

      UniProtKB/TrEMBL
      A0A8L2QVC0, A6HF61
      Conserved Domains (1) summary
      cd05332
      Location:41 → 302
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

    4. XM_039085406.2 → XP_038941334.1  dehydrogenase/reductase SDR family member 7B isoform X1

      UniProtKB/TrEMBL
      A0A8L2QVC0, A6HF61
      Conserved Domains (1) summary
      cd05332
      Location:41 → 302
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

    5. XM_006246472.5 → XP_006246534.1  dehydrogenase/reductase SDR family member 7B isoform X1

      See identical proteins and their annotated locations for XP_006246534.1

      UniProtKB/TrEMBL
      A0A8L2QVC0, A6HF61
      Conserved Domains (1) summary
      cd05332
      Location:41 → 302
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

    6. XM_063268623.1 → XP_063124693.1  dehydrogenase/reductase SDR family member 7B isoform X1

      UniProtKB/TrEMBL
      A0A8L2QVC0, A6HF61

    7. XM_006246473.5 → XP_006246535.1  dehydrogenase/reductase SDR family member 7B isoform X1

      See identical proteins and their annotated locations for XP_006246535.1

      UniProtKB/TrEMBL
      A0A8L2QVC0, A6HF61
      Related
      ENSRNOP00000063346.4, ENSRNOT00000066250.5
      Conserved Domains (1) summary
      cd05332
      Location:41 → 302
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5RJY4.1 GenPept UniProtKB/Swiss-Prot:Q5RJY4

    Gene LinkOut

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