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    Cep120 centrosomal protein 120 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307302, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cep120provided by RGD
    Official Full Name
    centrosomal protein 120provided by RGD
    Primary source
    RGD:1565619
    See related
    EnsemblRapid:ENSRNOG00000017035 AllianceGenome:RGD:1565619
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ccdc100; RGD1565619
    Summary
    Predicted to be involved in several processes, including interkinetic nuclear migration; positive regulation of cilium assembly; and regulation of centrosome duplication. Predicted to act upstream of or within several processes, including astral microtubule organization; nervous system development; and regulation of microtubule-based process. Predicted to be located in centriole. Predicted to be active in centrosome. Human ortholog(s) of this gene implicated in Joubert syndrome 31 and short-rib thoracic dysplasia 13 with or without polydactyly. Orthologous to human CEP120 (centrosomal protein 120). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 131.9), Lung (RPKM 111.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cep120 in Genome Data Viewer
    Location:
    18q11
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (49326266..49388380, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (47127979..47189964, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (48658495..48720570, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase C Neighboring gene PR/SET domain 6 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134483022 Neighboring gene translocase of inner mitochondrial membrane 23, pseudogene 2 Neighboring gene casein kinase 1, gamma 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Talpid3-binding centrosomal protein Cep120 is required for centriole duplication and proliferation of cerebellar granule neuron progenitors. Wu C, et al. PLoS One, 2014. PMID 25251415, Free PMC Article
    2. The transcription factor XBP-1 is essential for the development and survival of dendritic cells. Iwakoshi NN, et al. J Exp Med, 2007 Oct 1. PMID 17875675, Free PMC Article
    3. CEP295 interacts with microtubules and is required for centriole elongation. Chang CW, et al. J Cell Sci, 2016 Jul 1. PMID 27185865, Free PMC Article
    4. Cep120 and TACCs control interkinetic nuclear migration and the neural progenitor pool. Xie Z, et al. Neuron, 2007 Oct 4. PMID 17920017, Free PMC Article
    5. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within astral microtubule organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in centrosome cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cerebral cortex development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in interkinetic nuclear migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within interkinetic nuclear migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neurogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of centriole elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of centriole elongation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of centrosome duplication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of establishment of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of microtubule-based process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein of 120 kDa
    Names
    centrosomal protein 120kDa
    coiled-coil domain containing 100

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191697.1 → NP_001178626.1  centrosomal protein of 120 kDa

      See identical proteins and their annotated locations for NP_001178626.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A6IX35, D4A3J3
      Related
      ENSRNOP00000023236.6, ENSRNOT00000023236.8
      Conserved Domains (5) summary
      cd00030
      Location:531 → 564
      C2; C2 domain
      cl02553
      Location:703 → 928
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam12416
      Location:118 → 340
      DUF3668; Cep120 protein
      pfam17045
      Location:667 → 920
      CEP63; Centrosomal protein of 63 kDa
      cl14603
      Location:9 → 114
      C2; C2 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      49326266..49388380 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277302.1 → XP_063133372.1  centrosomal protein of 120 kDa isoform X1

      UniProtKB/TrEMBL
      A6IX35, D4A3J3

    2. XM_063277305.1 → XP_063133375.1  centrosomal protein of 120 kDa isoform X4

    3. XM_063277303.1 → XP_063133373.1  centrosomal protein of 120 kDa isoform X2

    4. XM_063277304.1 → XP_063133374.1  centrosomal protein of 120 kDa isoform X3

    RNA

    1. XR_010059566.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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