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    Tmtc1 transmembrane O-mannosyltransferase targeting cadherins 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362465, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmtc1provided by RGD
    Official Full Name
    transmembrane O-mannosyltransferase targeting cadherins 1provided by RGD
    Primary source
    RGD:1564868
    See related
    EnsemblRapid:ENSRNOG00000001854 AllianceGenome:RGD:1564868
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564868
    Summary
    Predicted to enable dolichyl-phosphate-mannose-protein mannosyltransferase activity. Predicted to be involved in protein O-linked mannosylation. Predicted to be located in endoplasmic reticulum and membrane. Orthologous to human TMTC1 (transmembrane O-mannosyltransferase targeting cadherins 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 100.8), Lung (RPKM 89.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmtc1 in Genome Data Viewer
    Location:
    4q44
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (182874350..183089408, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (181142937..181357979, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (182620132..182845620, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene fatty acyl CoA reductase 2 Neighboring gene ERGIC and golgi 2 Neighboring gene ribosomal protein S4, X-linked, pseudogene 13 Neighboring gene thymosin beta-10-like Neighboring gene uncharacterized LOC120102437

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Discovery of an O-mannosylation pathway selectively serving cadherins and protocadherins. Larsen ISB, et al. Proc Natl Acad Sci U S A, 2017 Oct 17. PMID 28973932, Free PMC Article
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables dolichyl-phosphate-mannose-protein mannosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein O-linked mannosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-linked mannosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein O-mannosyl-transferase TMTC1; transmembrane O-mannosyltransferase targeting cadherins 1
    Names
    transmembrane and TPR repeat-containing protein 1
    transmembrane and tetratricopeptide repeat containing 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431791.1 → NP_001418720.1  transmembrane O-mannosyltransferase targeting cadherins 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      D4A2M3

    2. NM_001431792.1 → NP_001418721.1  transmembrane O-mannosyltransferase targeting cadherins 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      182874350..183089408 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108900.2 → XP_038964828.1  protein O-mannosyl-transferase TMTC1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZZ24
      Related
      ENSRNOP00000084348.1, ENSRNOT00000114970.2
      Conserved Domains (3) summary
      TIGR02917
      Location:500 → 904
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:604 → 632
      TPR; TPR repeat [structural motif]
      pfam08409
      Location:352 → 425
      DUF1736; Domain of unknown function (DUF1736)

    2. XM_039108899.2 → XP_038964827.1  protein O-mannosyl-transferase TMTC1 isoform X1

      Related
      ENSRNOP00000100951.1, ENSRNOT00000144032.1
      Conserved Domains (3) summary
      TIGR02917
      Location:529 → 942
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:543 → 571
      TPR; TPR repeat [structural motif]
      pfam08409
      Location:352 → 425
      DUF1736; Domain of unknown function (DUF1736)

    3. XM_063286870.1 → XP_063142940.1  protein O-mannosyl-transferase TMTC1 isoform X4

      Related
      ENSRNOP00000109563.1, ENSRNOT00000160308.1

    4. XM_063286869.1 → XP_063142939.1  protein O-mannosyl-transferase TMTC1 isoform X3

      Related
      ENSRNOP00000103955.1, ENSRNOT00000158656.1

    5. XM_039108901.2 → XP_038964829.1  protein O-mannosyl-transferase TMTC1 isoform X5

      Conserved Domains (3) summary
      TIGR02917
      Location:505 → 649
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:543 → 571
      TPR; TPR repeat [structural motif]
      pfam08409
      Location:352 → 425
      DUF1736; Domain of unknown function (DUF1736)

    6. XM_039108902.2 → XP_038964830.1  protein O-mannosyl-transferase TMTC1 isoform X6

      Conserved Domains (1) summary
      pfam08409
      Location:352 → 425
      DUF1736; Domain of unknown function (DUF1736)
    Nucleotide Protein Strain
    Heading Accession and Version

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