Hs6st1 heparan sulfate 6-O-sulfotransferase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hs6st1provided by RGD
Official Full Name: heparan sulfate 6-O-sulfotransferase 1provided by RGD
Primary source: RGD:1309218
See related: EnsemblRapid:ENSRNOG00000014516 AllianceGenome:RGD:1309218
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable heparan sulfate 6-O-sulfotransferase activity. Predicted to be involved in heparan sulfate proteoglycan biosynthetic process, enzymatic modification and neuron development. Predicted to act upstream of or within blood vessel development; heparan sulfate proteoglycan biosynthetic process; and lung alveolus development. Predicted to be located in membrane. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 15 with or without anosmia. Orthologous to human HS6ST1 (heparan sulfate 6-O-sulfotransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 192.8), Lung (RPKM 159.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q21

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (45779402..45818583)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (38283502..38322684)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (42620006..42659184)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D9Got47 (e-PCR)
- UniSTS:115730

RH133575 (e-PCR)
- UniSTS:216858

AF045328 (e-PCR)
- UniSTS:32325

RH128830 (e-PCR)
- UniSTS:212138

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables heparan sulfate 6-O-sulfotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables heparan sulfate 6-O-sulfotransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heparan sulfate proteoglycan biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in heparan sulfate proteoglycan biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heparan sulfate proteoglycan biosynthetic process, enzymatic modification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within labyrinthine layer blood vessel development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung alveolus development	ISO Inferred from Sequence Orthology more info
involved_in neuron development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: heparan-sulfate 6-O-sulfotransferase 1

NP_001101680.1

EC 2.8.2.-

XP_038939488.1

EC 2.8.2.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108210.1 → NP_001101680.1 heparan-sulfate 6-O-sulfotransferase 1

See identical proteins and their annotated locations for NP_001101680.1

Status: PROVISIONAL

Source sequence(s)

CH473965

UniProtKB/TrEMBL

A6INC0

Related

ENSRNOP00000019966.6, ENSRNOT00000019966.8

Conserved Domains (1) summary

pfam03567
Location:3 → 268

Sulfotransfer_2; Sulfotransferase family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

45779402..45818583

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039083560.2 → XP_038939488.1 heparan-sulfate 6-O-sulfotransferase 1 isoform X1

UniProtKB/TrEMBL

A0A8I5Y4T0

Related

ENSRNOP00000076596.1, ENSRNOT00000119852.2

Conserved Domains (1) summary

cl22970
Location:65 → 247

Sulfotransfer_2; Sulfotransferase family