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    Prr4 proline rich 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360395, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prr4provided by RGD
    Official Full Name
    proline rich 4provided by RGD
    Primary source
    RGD:735181
    See related
    EnsemblRapid:ENSRNOG00000021313 AllianceGenome:RGD:735181
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CRP; Grpca; Grpcb; GRP-CA; GRP-CB
    Summary
    Predicted to be involved in biomineral tissue development. Predicted to be located in extracellular region. Orthologous to human PRR4 (proline rich 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Uterus (RPKM 8.8), Heart (RPKM 0.7) and 2 other tissues See more
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    Genomic context

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    See Prr4 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (168336501..168340300)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (166605104..166608903)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (167419911..167485225)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene SMR2 protein-like Neighboring gene proline rich protein HaeIII subfamily 1 Neighboring gene zinc finger HIT domain-containing protein 3 pseudogene Neighboring gene kidney androgen regulated protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Genes encoding proteins with homologous contiguous repeat sequences are highly expressed in the serous cells of the rat submandibular gland. Heinrich G, et al. J Biol Chem, 1987 Apr 15. PMID 3558393
    2. Molecular characterization of glutamic acid/glutamine-rich secretory proteins from rat submandibular glands. Mirels L, et al. J Biol Chem, 1987 May 25. PMID 2438276
    3. Secretagogue-coupled changes in the expression of glutamine/glutamic acid-rich proteins (GRPs). Isoproterenol induces changes in GRP transcript expression and changes in isoforms secreted. Cooper LF, et al. J Biol Chem, 1991 Feb 25. PMID 1995617
    4. Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy. Pieragostino D, et al. Mol Biosyst, 2013 Jun. PMID 23580065
    5. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Böhm D, et al. Oncol Rep, 2012 Aug. PMID 22664934, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biomineral tissue development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    submandibular gland secretory Glx-rich protein CB
    Names
    Submandibular gland secretory Glx-rich protein CA
    contiguous repeat polypeptide
    glutamine/glutamic acid-rich protein A
    glutamine/glutamic acid-rich protein B
    hypothetical gene supported by M31032, NM_181440
    rCG29588-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_203332.2 → NP_976077.2  submandibular gland secretory Glx-rich protein CB precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A0G2K5E1, A6IMC5
      Related
      ENSRNOP00000035576.7, ENSRNOT00000038396.7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      168336501..168340300
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08462.1 GenPept UniProtKB/Swiss-Prot:P08462

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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    Research Materials