Scn2b sodium voltage-gated channel beta subunit 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Scn2bprovided by RGD
Official Full Name: sodium voltage-gated channel beta subunit 2provided by RGD
Primary source: RGD:3633
See related: EnsemblRapid:ENSRNOG00000063505 AllianceGenome:RGD:3633
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: SCNB2
Summary: Enables sodium channel regulator activity and voltage-gated sodium channel activity. Involved in nervous system development and response to pyrethroid. Located in plasma membrane. Is active in axon initial segment and node of Ranvier. Used to study visual epilepsy. Biomarker of otitis media. Human ortholog(s) of this gene implicated in familial atrial fibrillation. Orthologous to human SCN2B (sodium voltage-gated channel beta subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 487.3) and Uterus (RPKM 54.0) See more
Orthologs: human mouse all
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Genomic context

Location:: 8q22

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (54322383..54334519)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (45425629..45437765)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (49419003..49431110)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Navbeta2 is a critical regulator of axonal excitability and synaptic function.
Title: Sodium Channel β2 Subunits Prevent Action Potential Propagation Failures at Axonal Branch Points.
distribution of SCN2B-containing neurons in the trigeminal ganglion
Title: SCN2B in the Rat Trigeminal Ganglion and Trigeminal Sensory Nuclei.
miR-9 suppressed the trafficking of Nav1.1/Nav1.2 from cytoplasm to cell membrane. miR-9 overexpression inhibited Navbeta2 expression by targeting its coding sequence domain.
Title: MicroRNA-9 induces defective trafficking of Nav1.1 and Nav1.2 by targeting Navβ2 protein coding region in rat with chronic brain hypoperfusion.
Through its role in regulating density of mature voltage-gated sodium channels in plasma membrane and modulating channel gating, beta2 subunit may affect development of ectopic activity in injured and non-injured sensory afferents and neuropathic pain.
Title: Upregulation of the voltage-gated sodium channel beta2 subunit in neuropathic pain models: characterization of expression in injured and non-injured primary sensory neurons.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sodium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium channel regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables sodium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	ISO Inferred from Sequence Orthology more info
enables voltage-gated sodium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated sodium channel activity involved in cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cardiac conduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within_positive_effect cardiac conduction	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle cell action potential involved in contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in cardiac muscle cell action potential involved in contraction	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_positive_effect gene expression	ISO Inferred from Sequence Orthology more info
involved_in membrane depolarization during action potential	ISO Inferred from Sequence Orthology more info
involved_in membrane depolarization during cardiac muscle cell action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in membrane depolarization during cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in membrane repolarization during ventricular cardiac muscle cell action potential	IEA Inferred from Electronic Annotation more info
involved_in nervous system development	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of sodium ion transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of atrial cardiac muscle cell membrane depolarization	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart rate by cardiac conduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to heat	ISO Inferred from Sequence Orthology more info
involved_in response to pyrethroid	IDA Inferred from Direct Assay more info	PubMed
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sodium ion transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in T-tubule	ISO Inferred from Sequence Orthology more info
located_in T-tubule	ISO Inferred from Sequence Orthology more info
is_active_in axon initial segment	IDA Inferred from Direct Assay more info	PubMed
is_active_in node of Ranvier	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of voltage-gated sodium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated sodium channel complex	ISO Inferred from Sequence Orthology more info
part_of voltage-gated sodium channel complex	ISS Inferred from Sequence or Structural Similarity more info
part_of voltage-gated sodium channel complex	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: sodium channel regulatory subunit beta-2; sodium channel subunit beta-2

Names: Sodium channel beta 2; sodium channel, voltage-gated, type II, beta polypeptide; sodium channel, voltage-gated, type II, beta subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012877.2 → NP_037009.1 sodium channel regulatory subunit beta-2 precursor

See identical proteins and their annotated locations for NP_037009.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

P54900

UniProtKB/TrEMBL

A6J429, Q62861

Related

ENSRNOP00000078627.1, ENSRNOT00000106113.2

Conserved Domains (2) summary

cd00096
Location:30 → 34

Ig; Ig strand A [structural motif]

cl11960
Location:30 → 146

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

54322383..54334519

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006242895.5 → XP_006242957.1 sodium channel subunit beta-2 isoform X1

UniProtKB/TrEMBL

Q62861

Conserved Domains (3) summary

smart00410
Location:6 → 121

IG_like; Immunoglobulin like

pfam06697
Location:127 → 162

DUF1191; Protein of unknown function (DUF1191)

cl11960
Location:2 → 117

Ig; Immunoglobulin domain