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    CDC7 cell division cycle 7 [ Homo sapiens (human) ]

    Gene ID: 8317, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CDC7provided by HGNC
    Official Full Name
    cell division cycle 7provided by HGNC
    Primary source
    HGNC:HGNC:1745
    See related
    Ensembl:ENSG00000097046 MIM:603311; AllianceGenome:HGNC:1745
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Hsk1; CDC7L1; HsCDC7; huCDC7
    Summary
    This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected. [provided by RefSeq, Aug 2008]
    Expression
    Broad expression in testis (RPKM 10.5), lymph node (RPKM 4.8) and 19 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CDC7 in Genome Data Viewer
    Location:
    1p22.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (91500851..91525764)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (91343613..91370396)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (91966408..91991321)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985417 Neighboring gene uncharacterized LOC105378856 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1303 Neighboring gene uncharacterized LOC102723436 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1304 Neighboring gene WD repeat domain 82 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1305 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:92047752-92048951 Neighboring gene ribosomal protein L39 pseudogene 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Cdc7 expression in melanomas, Spitz tumors and melanocytic nevi. Clarke LE, et al. J Cutan Pathol, 2009 Apr. PMID 19278428
    2. Cdc7 is an active kinase in human cancer cells undergoing replication stress. Tenca P, et al. J Biol Chem, 2007 Jan 5. PMID 17062569
    3. High expression of cell division cycle 7 protein correlates with poor prognosis in patients with diffuse large B-cell lymphoma. Hou Y, et al. Med Oncol, 2012 Dec. PMID 22528513
    4. Mechanism of cancer cell death induced by depletion of an essential replication regulator. Ito S, et al. PLoS One, 2012. PMID 22574151, Free PMC Article
    5. CDC7 kinase promotes MRE11 fork processing, modulating fork speed and chromosomal breakage. Rainey MD, et al. EMBO Rep, 2020 Aug 5. PMID 32496651, Free PMC Article

    See all (131) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DBF4, not DRF1, is the crucial regulator of CDC7 kinase at replication forks.
      Title: DBF4, not DRF1, is the crucial regulator of CDC7 kinase at replication forks.
    2. Druggable cavities and allosteric modulators of the cell division cycle 7 (CDC7) kinase.
      Title: Druggable cavities and allosteric modulators of the cell division cycle 7 (CDC7) kinase.
    3. DBF4 Dependent Kinase Inhibition Suppresses Hepatocellular Carcinoma Progression and Potentiates Anti-Programmed Cell Death-1 Therapy.
      Title: DBF4 Dependent Kinase Inhibition Suppresses Hepatocellular Carcinoma Progression and Potentiates Anti-Programmed Cell Death-1 Therapy.
    4. Novel insights into the roles of Cdc7 in response to replication stress.
      Title: Novel insights into the roles of Cdc7 in response to replication stress.
    5. Targeting CDC7 potentiates ATR-CHK1 signaling inhibition through induction of DNA replication stress in liver cancer.
      Title: Targeting CDC7 potentiates ATR-CHK1 signaling inhibition through induction of DNA replication stress in liver cancer.
    6. MiR-200a with CDC7 as a direct target declines cell viability and promotes cell apoptosis in Wilm's tumor via Wnt/beta-catenin signaling pathway.
      Title: MiR-200a with CDC7 as a direct target declines cell viability and promotes cell apoptosis in Wilm's tumor via Wnt/β-catenin signaling pathway.
    7. Upregulation of CDC7 Associated with Cervical Cancer Incidence and Development.
      Title: Upregulation of CDC7 Associated with Cervical Cancer Incidence and Development.
    8. ATR Restrains DNA Synthesis and Mitotic Catastrophe in Response to CDC7 Inhibition.
      Title: ATR Restrains DNA Synthesis and Mitotic Catastrophe in Response to CDC7 Inhibition.
    9. CDC7 kinase promotes MRE11 fork processing, modulating fork speed and chromosomal breakage.
      Title: CDC7 kinase promotes MRE11 fork processing, modulating fork speed and chromosomal breakage.
    10. Cdc7 kinase stimulates Aurora B kinase in M-phase.
      Title: Cdc7 kinase stimulates Aurora B kinase in M-phase.
    Submit: New GeneRIF Correction See all GeneRIFs (65)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study of optic disc parameters.
    EBI GWAS Catalog
    Genome-wide association studies in Asians confirm the involvement of ATOH7 and TGFBR3, and further identify CARD10 as a novel locus influencing optic disc area.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC117361, MGC126237, MGC126238

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cell cycle phase transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via break-induced replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of nuclear cell cycle DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intercellular bridge IDA
    Inferred from Direct Assay
    more info
    		  
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cell division cycle 7-related protein kinase
    Names
    CDC7 (cell division cycle 7, S. cerevisiae, homolog)-like 1
    CDC7-related kinase
    cell division cycle 7 homolog
    cell division cycle 7-like protein 1
    epididymis secretory sperm binding protein
    NP_001127891.1
    NP_001127892.1
    NP_003494.1
    XP_005271298.1
    XP_005271301.1
    XP_016857914.1
    XP_016857915.1
    XP_016857916.1
    XP_024305858.1
    XP_047287315.1
    XP_047287320.1
    XP_047287321.1
    XP_047287328.1
    XP_047287329.1
    XP_047287330.1
    XP_047287331.1
    XP_047287332.1
    XP_054194913.1
    XP_054194914.1
    XP_054194915.1
    XP_054194916.1
    XP_054194917.1
    XP_054194918.1
    XP_054194919.1
    XP_054194920.1
    XP_054194921.1
    XP_054194922.1
    XP_054194923.1
    XP_054194924.1
    XP_054194925.1
    XP_054194926.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134419.2 → NP_001127891.1  cell division cycle 7-related protein kinase

      See identical proteins and their annotated locations for NP_001127891.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 all encode the same protein.
      Source sequence(s)
      AI672674, BC110526, BC111044, DA791490, N62245
      Consensus CDS
      CCDS734.1
      UniProtKB/Swiss-Prot
      D3DT31, O00311, O00558, Q5T5U5
      UniProtKB/TrEMBL
      A0A384MTU6, B2R6V2
      Conserved Domains (2) summary
      cd14019
      Location:56 → 438
      STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase
      cl21453
      Location:293 → 419
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001134420.2 → NP_001127892.1  cell division cycle 7-related protein kinase

      See identical proteins and their annotated locations for NP_001127892.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses a different segment for part of its 5' UTR, compared to variant 1. Variants 1, 2, and 3 all encode the same protein.
      Source sequence(s)
      AI672674, AK312726, BC111044, DA127303, N62245
      Consensus CDS
      CCDS734.1
      UniProtKB/Swiss-Prot
      D3DT31, O00311, O00558, Q5T5U5
      UniProtKB/TrEMBL
      A0A384MTU6, B2R6V2
      Related
      ENSP00000393139.1, ENST00000428239.5
      Conserved Domains (2) summary
      cd14019
      Location:56 → 438
      STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase
      cl21453
      Location:293 → 419
      PKc_like; Protein Kinases, catalytic domain

    3. NM_003503.4 → NP_003494.1  cell division cycle 7-related protein kinase

      See identical proteins and their annotated locations for NP_003494.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the most commonly occurring transcript. Variants 1, 2, and 3 all encode the same protein.
      Source sequence(s)
      AI672674, BC111044, DA791490, N62245
      Consensus CDS
      CCDS734.1
      UniProtKB/Swiss-Prot
      D3DT31, O00311, O00558, Q5T5U5
      UniProtKB/TrEMBL
      A0A384MTU6, B2R6V2
      Related
      ENSP00000234626.6, ENST00000234626.11
      Conserved Domains (2) summary
      cd14019
      Location:56 → 438
      STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase
      cl21453
      Location:293 → 419
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      91500851..91525764
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005271244.4 → XP_005271301.1  cell division cycle 7-related protein kinase isoform X2

      UniProtKB/TrEMBL
      B2R6V2
      Conserved Domains (3) summary
      cd14019
      Location:56 → 406
      STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase
      pfam00069
      Location:58 → 417
      Pkinase; Protein kinase domain
      cl21453
      Location:314 → 537
      PKc_like; Protein Kinases, catalytic domain

    2. XM_017002426.2 → XP_016857915.1  cell division cycle 7-related protein kinase isoform X2

      UniProtKB/TrEMBL
      B2R6V2
      Conserved Domains (3) summary
      cd14019
      Location:56 → 406
      STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase
      pfam00069
      Location:58 → 417
      Pkinase; Protein kinase domain
      cl21453
      Location:314 → 537
      PKc_like; Protein Kinases, catalytic domain

    3. XM_017002427.3 → XP_016857916.1  cell division cycle 7-related protein kinase isoform X3

      UniProtKB/TrEMBL
      B7Z5H7
      Conserved Domains (1) summary
      cl21453
      Location:1 → 321
      PKc_like; Protein Kinases, catalytic domain

    4. XM_047431372.1 → XP_047287328.1  cell division cycle 7-related protein kinase isoform X4

    5. XM_005271241.3 → XP_005271298.1  cell division cycle 7-related protein kinase isoform X1

      See identical proteins and their annotated locations for XP_005271298.1

      UniProtKB/Swiss-Prot
      D3DT31, O00311, O00558, Q5T5U5
      UniProtKB/TrEMBL
      A0A384MTU6, B2R6V2
      Conserved Domains (2) summary
      cd14019
      Location:56 → 438
      STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase
      cl21453
      Location:293 → 419
      PKc_like; Protein Kinases, catalytic domain

    6. XM_017002425.3 → XP_016857914.1  cell division cycle 7-related protein kinase isoform X2

      UniProtKB/TrEMBL
      B2R6V2
      Conserved Domains (3) summary
      cd14019
      Location:56 → 406
      STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase
      pfam00069
      Location:58 → 417
      Pkinase; Protein kinase domain
      cl21453
      Location:314 → 537
      PKc_like; Protein Kinases, catalytic domain

    7. XM_047431374.1 → XP_047287330.1  cell division cycle 7-related protein kinase isoform X5

    8. XM_047431373.1 → XP_047287329.1  cell division cycle 7-related protein kinase isoform X5

    9. XM_047431376.1 → XP_047287332.1  cell division cycle 7-related protein kinase isoform X6

      UniProtKB/TrEMBL
      Q59FX2

    10. XM_047431375.1 → XP_047287331.1  cell division cycle 7-related protein kinase isoform X5

    11. XM_047431364.1 → XP_047287320.1  cell division cycle 7-related protein kinase isoform X2

      UniProtKB/TrEMBL
      B2R6V2

    12. XM_047431359.1 → XP_047287315.1  cell division cycle 7-related protein kinase isoform X1

      UniProtKB/Swiss-Prot
      D3DT31, O00311, O00558, Q5T5U5
      UniProtKB/TrEMBL
      A0A384MTU6, B2R6V2

    13. XM_024450090.2 → XP_024305858.1  cell division cycle 7-related protein kinase isoform X1

      UniProtKB/Swiss-Prot
      D3DT31, O00311, O00558, Q5T5U5
      UniProtKB/TrEMBL
      A0A384MTU6, B2R6V2
      Conserved Domains (2) summary
      cd14019
      Location:56 → 438
      STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase
      cl21453
      Location:293 → 419
      PKc_like; Protein Kinases, catalytic domain

    14. XM_047431365.1 → XP_047287321.1  cell division cycle 7-related protein kinase isoform X2

      UniProtKB/TrEMBL
      B2R6V2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      91343613..91370396
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338941.1 → XP_054194916.1  cell division cycle 7-related protein kinase isoform X1

      UniProtKB/Swiss-Prot
      D3DT31, O00311, O00558, Q5T5U5
      UniProtKB/TrEMBL
      A0A384MTU6, B2R6V2

    2. XM_054338940.1 → XP_054194915.1  cell division cycle 7-related protein kinase isoform X1

      UniProtKB/Swiss-Prot
      D3DT31, O00311, O00558, Q5T5U5
      UniProtKB/TrEMBL
      A0A384MTU6, B2R6V2

    3. XM_054338946.1 → XP_054194921.1  cell division cycle 7-related protein kinase isoform X2

      UniProtKB/TrEMBL
      B2R6V2

    4. XM_054338942.1 → XP_054194917.1  cell division cycle 7-related protein kinase isoform X2

      UniProtKB/TrEMBL
      B2R6V2

    5. XM_054338944.1 → XP_054194919.1  cell division cycle 7-related protein kinase isoform X2

      UniProtKB/TrEMBL
      B2R6V2

    6. XM_054338947.1 → XP_054194922.1  cell division cycle 7-related protein kinase isoform X3

      UniProtKB/TrEMBL
      B7Z5H7

    7. XM_054338948.1 → XP_054194923.1  cell division cycle 7-related protein kinase isoform X4

    8. XM_054338949.1 → XP_054194924.1  cell division cycle 7-related protein kinase isoform X5

    9. XM_054338951.1 → XP_054194926.1  cell division cycle 7-related protein kinase isoform X6

      UniProtKB/TrEMBL
      Q59FX2

    10. XM_054338950.1 → XP_054194925.1  cell division cycle 7-related protein kinase isoform X5

    11. XM_054338938.1 → XP_054194913.1  cell division cycle 7-related protein kinase isoform X1

      UniProtKB/Swiss-Prot
      D3DT31, O00311, O00558, Q5T5U5
      UniProtKB/TrEMBL
      A0A384MTU6, B2R6V2

    12. XM_054338943.1 → XP_054194918.1  cell division cycle 7-related protein kinase isoform X2

      UniProtKB/TrEMBL
      B2R6V2

    13. XM_054338939.1 → XP_054194914.1  cell division cycle 7-related protein kinase isoform X1

      UniProtKB/Swiss-Prot
      D3DT31, O00311, O00558, Q5T5U5
      UniProtKB/TrEMBL
      A0A384MTU6, B2R6V2

    14. XM_054338945.1 → XP_054194920.1  cell division cycle 7-related protein kinase isoform X2

      UniProtKB/TrEMBL
      B2R6V2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O00311.1 GenPept UniProtKB/Swiss-Prot:O00311

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