Ajap1 adherens junction associated protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ajap1provided by MGI
Official Full Name: adherens junction associated protein 1provided by MGI
Primary source: MGI:MGI:2685419
See related: Ensembl:ENSMUSG00000039546 AllianceGenome:MGI:2685419
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm573
Summary: Enables protein domain specific binding activity. Predicted to be involved in negative regulation of cell-matrix adhesion; negative regulation of wound healing; and regulation of polarized epithelial cell differentiation. Predicted to be located in basolateral plasma membrane and cell surface. Predicted to be active in adherens junction; cell-cell contact zone; and cytoplasmic side of plasma membrane. Is expressed in several structures, including adrenal gland; brain; eye; genitourinary system; and spinal cord. Orthologous to human AJAP1 (adherens junctions associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in frontal lobe adult (RPKM 5.3), cortex adult (RPKM 4.3) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 E2; 4 83.71 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (153457678..153568313, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (153373221..153483795, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Monoallelic de novo AJAP1 loss-of-function variants disrupt trans-synaptic control of neurotransmitter release.
Title: Monoallelic de novo AJAP1 loss-of-function variants disrupt trans-synaptic control of neurotransmitter release.
AJAP1 affects behavioral changes and GABABR1 level in epileptic mice.
Title: AJAP1 affects behavioral changes and GABA(B)R1 level in epileptic mice.
The findings suggested that miR-552 promotes hepatocellular carcinoma oncogenesis and progression by inhibiting AJAP1 expression.
Title: MiR-552 promotes the proliferation, migration and EMT of hepatocellular carcinoma cells by inhibiting AJAP1 expression.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables beta-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables beta-catenin binding	IEA Inferred from Electronic Annotation more info
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables protein domain specific binding	IDA Inferred from Direct Assay more info	PubMed
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of wound healing	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of wound healing	ISO Inferred from Sequence Orthology more info
involved_in regulation of polarized epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of polarized epithelial cell differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in cell-cell contact zone	IBA Inferred from Biological aspect of Ancestor more info
located_in cell-cell contact zone	IEA Inferred from Electronic Annotation more info
located_in cell-cell contact zone	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasmic side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: adherens junction-associated protein 1

Names: likely ortholog of H. sapiens transmembrane protein SHREW1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001099299.1 → NP_001092769.1 adherens junction-associated protein 1 precursor

See identical proteins and their annotated locations for NP_001092769.1

Status: VALIDATED

Source sequence(s)

AL805910, AL954390

Consensus CDS

CCDS38987.1

UniProtKB/Swiss-Prot

A2ALI5, B2RVK0

Related

ENSMUSP00000101271.2, ENSMUST00000105646.3

Conserved Domains (1) summary

pfam15298
Location:181 → 389

AJAP1_PANP_C; AJAP1/PANP C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

153457678..153568313 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006538824.5 → XP_006538887.1 adherens junction-associated protein 1 isoform X1

Conserved Domains (1) summary

pfam15298
Location:178 → 386

AJAP1_PANP_C; AJAP1/PANP C-terminus